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Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Department of Cardiology, Affiliated Hospital of Jiangsu University.ORCID iD: 0000-0002-4344-6825
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
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2019 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 519, no 3, p. 469-474Article in journal (Refereed) Published
Abstract [en]

Dual specificity phosphatase (DUSP) 4 has been described as a negative regulator of MAP kinase signaling, in particular for the ERK1/2 and JNK pathways. We found that DUSP4 expression was upregulated in response to prolonged platelet-derived growth factor (PDGF)-BB stimulation. The PDGF-BB-induced DUSP4 expression was dependent on ERK1/2, STAT3 and p53. We found that inhibition of ERK1/2 effectively reduced DUSP4 mRNA levels, whereas STAT3 was necessary for maintaining p53 expression. p53 has binding sites in the DUSP4 promoter and was found to promote DUSP4 expression.

Place, publisher, year, edition, pages
2019. Vol. 519, no 3, p. 469-474
Keywords [en]
DUSP4, Erk1/2, Multifactor regulation, PDGF, STAT3, p53
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-400210DOI: 10.1016/j.bbrc.2019.09.014ISI: 000506407800004PubMedID: 31526568OAI: oai:DiVA.org:uu-400210DiVA, id: diva2:1380549
Funder
Swedish Cancer Society, 2018/425Swedish Cancer Society, 2016/445
Note

De 2 första författarna delar förstaförfattarskapet

Available from: 2019-12-19 Created: 2019-12-19 Last updated: 2020-03-24Bibliographically approved

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Yin, RuntingEger, GlendaSarri, NikiRorsman, CharlotteHeldin, Carl-HenrikLennartsson, Johan

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Yin, RuntingEger, GlendaSarri, NikiRorsman, CharlotteHeldin, Carl-HenrikLennartsson, Johan
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Ludwig Institute for Cancer ResearchDepartment of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLabDepartment of Pharmaceutical Biosciences
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Biochemical and Biophysical Research Communications - BBRC
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