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Adenovirus in the omics era - a multi-pronged strategy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2019 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468Article in journal (Refereed) Epub ahead of print
Abstract [en]

Human adenoviruses (HAdVs) are common pathogens associated with a wide variety of respiratory, ocular and gastrointestinal diseases. To achieve its effective lytic mode of replication, HAdVs have to reprogram host-cell gene expression and fine-tune viral gene expression in a temporal manner. In two decades, omics revolution has advanced our knowledge about the HAdV and host cell interplay at the RNA and protein levels. This review summarizes the current knowledge from large-scale datasets how HAdV infections adjust coding and non-coding RNA expression, as well as how they reprogram host-cell proteome during the lytic course of infection.

Place, publisher, year, edition, pages
2019.
Keywords [en]
HAdV infection, RNA seq, SILAC-MS, Virus-host interaction, lncRNA, miRNA, mivaRNA, proteomics, regulation of host-cell genes expression, transcriptomics
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-400689DOI: 10.1002/1873-3468.13710PubMedID: 31811727OAI: oai:DiVA.org:uu-400689DiVA, id: diva2:1382123
Available from: 2020-01-02 Created: 2020-01-02 Last updated: 2020-01-02

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