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Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics
Linkoping Univ, Dept Med & Hlth Sci, SE-58183 Linkoping, Sweden;Karolinska Inst, Dept Oncol Pathol, SE-17176 Stockholm, Sweden.
Karolinska Inst, Dept Oncol Pathol, SE-17176 Stockholm, Sweden.ORCID iD: 0000-0003-2591-2914
Gebze Tech Univ, Dept Mol Biol & Genet, TR-41400 Gebze, Kocaeli, Turkey.ORCID iD: 0000-0001-6272-7158
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
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2016 (English)In: TRENDS IN CANCER, ISSN 2405-8025, Vol. 2, no 11, p. 657-663Article, review/survey (Refereed) Published
Abstract [en]

The presence of quiescent cell populations in solid tumors represents a major challenge for disease eradication. Such cells are generally present in poorly vascularized tumor areas, show limited sensitivity to traditional chemotherapeutical drugs, and tend to resume proliferation, resulting in tumor reseeding and growth. There is growing recognition of the importance of developing therapies that target these quiescent cell populations to achieve long-lasting remission. Recent studies have shown that the combination of hypoxia and reduced nutrient availability in poorly vascularized areas results in limited tumor metabolic plasticity coupled with an increased sensitivity to perturbations in mitochondrial flux. Targeting of mitochondrial bioenergetics in these quiescent cell tumor populations may enable tumor eradication and improve the prognosis of patients with cancer.

Place, publisher, year, edition, pages
2016. Vol. 2, no 11, p. 657-663
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-400847DOI: 10.1016/j.trecan.2016.10.009ISI: 000432227400005PubMedID: 28741504OAI: oai:DiVA.org:uu-400847DiVA, id: diva2:1382989
Funder
Swedish Research CouncilSwedish Cancer SocietySwedish Childhood Cancer FoundationKnut and Alice Wallenberg FoundationAvailable from: 2020-01-07 Created: 2020-01-07 Last updated: 2020-01-07Bibliographically approved

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Gullbo, Joachim

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