uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Nanodelivery of cerebrolysin reduces pathophysiology of Parkinson's disease
Univ Arkansas, Dept Biomed Engn, Fayetteville, AR 72701 USA.ORCID iD: 0000-0002-6261-9533
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Spain.ORCID iD: 0000-0001-7246-0987
Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania.
Show others and affiliations
2019 (English)In: NANONEUROPROTECTION AND NANONEUROTOXICOLOGY / [ed] Sharma, A Sharma, HS, ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD , 2019, p. 201-246Chapter in book (Refereed)
Abstract [en]

Parkinson's disease (PD) is affecting >10 million people worldwide for which no suitable cure has been developed so far. Roughly, about two people per thousand populations are affected with PD like symptoms especially over the age of 50. About 1% of the populations above 60 years suffer from PD-like disease. The prevalence of the disease is increasing over the years, and future projections by 2020 could be 12-14 millions people affected by the disease. Thus, exploration of suitable therapeutic measures is the need of the hour to enhance quality of the life of PD patients. PD induced brain pathology includes loss of dopaminergic neurons in the substantia niagra that could later extends to other cortical regions causing loss of voluntary motor control. Deposition of alpha-synuclein in the brain further leads to neurodegeneration. However, the exact cause of PD is still unknown. It appears that breakdown of the blood-brain barrier (BBB) and leakage of serum component into the brain could lead to neurodegeneration in PD. Thus, novel treatment strategies that are able to restore BBB breakdown and enhance neuronal plasticity and neuroregeneration in PD could be effective in future therapy. With the advancement of nanotechnology, it is worthwhile to understand the role of nanodelivery of selected agents in PD to enhance neuroprotection. In this review new role of BBB, brain edema, and neuropathology in PD is discussed. In addition, superior neuroprotection induced by nanowired delivery of a multimodal drug cerebrolysin in PD is summarized based on our own investigations.

Place, publisher, year, edition, pages
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD , 2019. p. 201-246
Series
Progress in Brain Research, ISSN 0079-6123 ; 245
Keywords [en]
Parkinson's disease, Blood-brain barrier, Brain edema, Alpha-synuclein, Cerebrolysin, Nanowired delivery
National Category
Neurology Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-401953DOI: 10.1016/bs.pbr.2019.03.014ISI: 000500699500007PubMedID: 30961868Libris ID: nzjf9glllk88j4zrISBN: 978-0-444-64208-0 (electronic)OAI: oai:DiVA.org:uu-401953DiVA, id: diva2:1384559
Available from: 2020-01-10 Created: 2020-01-10 Last updated: 2020-01-10Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Sharma, ArunaSharma, Hari Shanker

Search in DiVA

By author/editor
Ozkizilcik, AsyaSharma, ArunaVicente Lafuente, JoseSharma, Hari Shanker
By organisation
Anaesthesiology and Intensive Care
NeurologyNeurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
isbn
urn-nbn

Altmetric score

doi
pubmed
isbn
urn-nbn
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf