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Sleep deprivation exacerbates concussive head injury induced brain pathology: Neuroprotective effects of nanowired delivery of cerebrolysin with alpha-melanocyte-stimulating hormone
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania.
Univ Arkansas, Dept Biomed Engn, Fayetteville, AR 72701 USA.ORCID iD: 0000-0002-6261-9533
Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
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2019 (English)In: NANONEUROPROTECTION AND NANONEUROTOXICOLOGY / [ed] Sharma, A Sharma, HS, ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD , 2019, p. 1-55Chapter in book (Refereed)
Abstract [en]

Sleep deprivation (SD) is very common in military personnel resulting in mental anomalies and interfering with decision-making capabilities. Moreover during combat operation, these sleep-deprived soldiers often receive blunt head trauma casing concussive head injury (CHI). Recent observations clearly suggest that SD alone induces brain pathology and additional CHI further exacerbates brain damage. Thus, the need of the hour is to explore possible effective therapeutic measures to induce neuroprotection to enhance quality of life of these military personnel. This review deals with novel aspects of treatment using nanotechnology to induce superior neuroprotection following CHI in SD based on our own investigation in the light of recent literature in the field.

Place, publisher, year, edition, pages
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD , 2019. p. 1-55
Series
Progress in Brain Research, ISSN 0079-6123 ; 245
Keywords [en]
Sleep deprivation, Concussive head injury, Cerebrolysin, alpha-Melanocyte stimulating hormone, Brain pathology, Blood-brain barrier, Brain edema
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-401954DOI: 10.1016/bs.pbr.2019.03.002ISI: 000500699500002PubMedID: 30961865Libris ID: nzjf9glllk88j4zrISBN: 978-0-444-64208-0 (electronic)OAI: oai:DiVA.org:uu-401954DiVA, id: diva2:1384565
Available from: 2020-01-10 Created: 2020-01-10 Last updated: 2020-01-10Bibliographically approved

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Sharma, ArunaSharma, Hari Shanker

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