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Leakage of the blood-brain barrier followed by vasogenic edema as the ultimate cause of death induced by acute methamphetamine overdose
NIDA, Behav Neurosci Branch, Intramural Res Program, NIH,DHHS, Baltimore, MD 20892 USA.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2019 (English)In: New Therapeutic Strategies for Brain Edema and Cell Injury / [ed] Sharma, HS Sharma, A, Elsevier, 2019, p. 189-207Chapter in book (Refereed)
Abstract [en]

Methamphetamine (METH) is a potent CNS stimulant that is widely used as a recreational drug. Due to its ability to increase bodily heat production and diminish heat loss due to peripheral vasoconstriction, METH is able to increase brain and body temperature. The hyperthermic effects of METH are potentiated when the drug is used under conditions of psycho-physiological activation and in warm ambient temperatures. In this short review, we present and discuss our data on the effects of METH on brain temperature and a number of neural parameters that characterize permeability of the blood-brain barrier (albumin immunoreactivity), glial activity (GFAP immunoreactivity), brain tissue water content, and structural abnormalities of brain cells. We demonstrate that the extent of these neural alterations strongly depends on METH-induced brain temperature elevation and they all dramatically increase following exposure to METH in warm (29 degrees C) vs. standard (23 degrees C) ambient temperatures. Based on these data weconsider possible pathophysiological mechanisms underlying acute METH toxicity, suggesting the critical role of drug-induced brain hyperthermia, temperature-dependent leakage of the blood-brain barrier (BBB), and the development of vasogenic edema that could finally result in decompensation of vital functions and death.

Place, publisher, year, edition, pages
Elsevier, 2019. p. 189-207
Series
International Review of Neurobiology, ISSN 0074-7742 ; 146
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-401925DOI: 10.1016/bs.irn.2019.06.010ISI: 000501592100007PubMedID: 31349927ISBN: 978-0-12-816754-0 (print)OAI: oai:DiVA.org:uu-401925DiVA, id: diva2:1384791
Funder
NIH (National Institute of Health)Available from: 2020-01-10 Created: 2020-01-10 Last updated: 2020-01-10Bibliographically approved

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Sharma, Hari Shanker

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