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Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)
Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland;Univ Eastern Finland, Sch Pharm, Kuopio, Finland.ORCID iD: 0000-0003-0825-4956
Univ Eastern Finland, Sch Pharm, Kuopio, Finland.
Univ Eastern Finland, Sch Pharm, Kuopio, Finland;Bioctr Kuopio, LC MS Metabol Ctr, Kuopio, Finland.
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2019 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 110, no 5, p. 1108-1118Article in journal (Refereed) Published
Abstract [en]

Background: Recently, a group of betainized compounds have been suggested to play a role in health effects in relation to a whole-grain-rich diet.

Objectives: The aims of this study were to develop a quantitative mass spectrometric method for selected betainized compounds in human plasma, and to investigate their association with nutrient intake and measures of metabolic health in participants of the SYSDIET study.

Methods: The SYSDIET study was a controlled randomized intervention including individuals with metabolic syndrome, where the healthy Nordic diet (HND) group increased intakes of whole grains, canola oil, berries, and fish, whereas the control diet (CD) group consumed low-fiber cereal products, milk fat, and restricted amounts of fish and berries. A quantitative LC combined with triple quadrupole MS method for betainized compounds was developed and applied to fasting plasma samples from baseline (week 0) and the end of the intervention (week 18 or 24). Concentrations of betainized compounds were correlated with intakes of selected nutrients and fiber and measures of metabolic health.

Results: Pipecolic acid betaine (PAB) concentrations were significantly higher in the HND group than in the CD group (P = 0.00032) at the end of the intervention and correlated directly (P < 0.0001) with intakes of dietary fiber (r = 0.376) and a biomarker related to whole-grain rye intake, namely the ratio of alkylresorcinol C17:0 to C21:0 (r = 0.442). PAB was associated inversely with fasting plasma insulin consistently at the beginning and at the end of the intervention (P < 0.001, r = -0.300; P < 0.01, r = -0.250, respectively), as well as IL-1 receptor antagonist (P < 0.01, r = -0.232 at the beginning; P < 0.01, r = -0.236 at the end) and serum LDL/HDL cholesterol (P < 0.01, r = -0.239 at the beginning; P < 0.01, r = -0.241 at the end).

Conclusions: Among adults with the metabolic syndrome, PAB plasma concentrations were associated with fasting insulin, inflammation, and lipids and were significantly increased with adoption of the HND. Further studies are needed to clarify the biological functions of betainized compounds.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2019. Vol. 110, no 5, p. 1108-1118
Keywords [en]
betainized compounds, fiber, healthy Nordic diet, LC-QQQ-MS, pipecolic acid betaine, quantitative, rye, whole grain
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:uu:diva-402660DOI: 10.1093/ajcn/nqz179ISI: 000504093300012PubMedID: 31504116OAI: oai:DiVA.org:uu-402660DiVA, id: diva2:1386958
Funder
NordForsk, 070014Swedish Heart Lung FoundationSwedish Diabetes AssociationAvailable from: 2020-01-20 Created: 2020-01-20 Last updated: 2020-01-20Bibliographically approved

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