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Zinc finger proteins in psychiatric disorders and response to psychotropic medications
Univ Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, Cagliari, Italy;Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada.
Univ Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, Cagliari, Italy.
Univ Hosp Cagliari, Unit Clin Pharmacol, Cagliari, Italy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Schiöth: Functional Pharmacology. Univ Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, Cagliari, Italy.ORCID iD: 0000-0002-9151-4319
2019 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 29, no 5, p. 132-141Article, review/survey (Refereed) Published
Abstract [en]

Zinc finger proteins are a large family of abundantly expressed small motifs that play a crucial role in a wide range of physiological and pathophysiological mechanisms. Findings published so far support an involvement of zinc fingers in psychiatric disorders. Most of the evidence has been provided for the zinc finger protein 804A (ZNF804A) gene, which has been suggested to be implicated in schizophrenia and bipolar disorder. This evidence has been corroborated by a wide range of functional studies showing that ZNF804A regulates the expression of genes involved in cell adhesion and plays a crucial role in neurite formation and maintenance of dendritic spines. On the other hand, far less is known on other zinc finger proteins and their involvement in psychiatric disorders. In this review, we discussed studies exploring the role of zinc finger proteins in schizophrenia, bipolar disorder, and major depressive disorder as well as in pharmacogenetics of psychotropic drugs.

Place, publisher, year, edition, pages
2019. Vol. 29, no 5, p. 132-141
Keywords [en]
antidepressants, antipsychotics, bipolar disorder, lithium, major depressive disorder, pharmacogenetics, personalized medicine, schizophrenia, zinc finger genes, zinc finger protein 804A
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-407176DOI: 10.1097/YPG.0000000000000231ISI: 000509479500002PubMedID: 31464994OAI: oai:DiVA.org:uu-407176DiVA, id: diva2:1416232
Available from: 2020-03-23 Created: 2020-03-23 Last updated: 2020-03-23Bibliographically approved

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