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Evidence for Wg-independent tergite boundary formation in the millipede Glomeris marginata
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
Institute for Genetics, University of Cologne, Köln, Germany.
Johann-Friedrich-Blumenbach Institut für Zoologie und Anthropologie, Abteilung für Entwicklungsbiologie, GZMB, Georg-August-Universität Göttingen, Germany.
2008 (English)In: Development, Genes and Evolution, ISSN 0949-944X, E-ISSN 1432-041X, Vol. 218, no 7, 361-370 p.Article in journal (Refereed) Published
Abstract [en]

The correlation between dorsal and ventral segmental units in diplopod myriapods is complex and disputed. Recent results with engrailed (en), hedgehog (hh), wingless (wg), and cubitus-interruptus (ci) have shown that the dorsal segments are patterned differently from the ventral segments. Ventrally, gene expression is compatible with the classical autoregulatory loop known from Drosophila to specify the parasegment boundary. In the dorsal segments, however, this Wg/Hh autoregulatory loop cannot be present because the observed gene expression patterns argue against the involvement of Wg signalling. In this paper, we present further evidence against an involvement of Wg signalling in dorsal segmentation and propose a hypothesis about how dorsal segmental boundaries may be controlled in a wg-independent way. We find that (1) the Notum gene, a modulator of the Wg gradient in Drosophila, is not expressed in the dorsal segments. (2) The H15/midline gene, a repressor of Wg action in Drosophila, is not expressed in the dorsal segments, except for future heart tissue. (3) The patched (ptc) gene, which encodes a Hh receptor, is strongly expressed in the dorsal segments, which is incompatible with Wg-Hh autoregulation. The available data suggest that anterior-posterior (AP) boundary formation in dorsal segments could instead rely on Dpp signalling rather than Wg signalling. We present a hypothesis that relies on Hh-mediated activation of Dpp signalling and optomotor-blind (omb) expression to establish the dorsal AP boundary (the future tergite boundary). The proposed mechanism is similar to the mechanism used to establish the AP boundary in Drosophila wings and ventral pleura.

Place, publisher, year, edition, pages
2008. Vol. 218, no 7, 361-370 p.
Keyword [en]
myriapoda, segmentation, arthropod evolution, segment polarity genes, boundary formation
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-88293DOI: 10.1007/s00427-008-0231-2ISI: 000257395200003OAI: oai:DiVA.org:uu-88293DiVA: diva2:145396
Available from: 2009-01-28 Created: 2009-01-28 Last updated: 2017-12-14Bibliographically approved

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Janssen, RalfBudd, Graham E.

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