uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The occurrence of invasive cancers following a diagnosis of breast carcinoma in situ
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
2008 (English)In: British Journal of Cancer, ISSN 0007-0920, Vol. 99, no 4, 611-5 p.Article in journal (Refereed) Published
Abstract [en]

Approximately 1 in every 600 women attending breast-screening programmes in the United Kingdom is diagnosed with breast carcinoma in situ (BCIS). However, there is little information on the occurrence of subsequent cancers (other than second breast cancers) in these women. We investigated the occurrence of invasive cancers in 12,836 women diagnosed with BCIS in southeast England between 1971 and 2003, using data from the Thames Cancer Registry. A greater than expected number of subsequent cancers was found for two sites: breast (standardised incidence ratio (SIR) 1.96; 95% confidence interval (CI) 1.79-2.14) and corpus uteri (SIR 1.42; 95% CI 1.11-1.78). For subsequent ipsilateral breast cancer in those treated with breast conservation, the excess was independent of the time since diagnosis of BCIS, whereas for subsequent contralateral breast cancer, there was a steady decline in excess over time. For subsequent uterine cancer, the excess became statistically significant only at >5 years after BCIS diagnosis, consistent with a treatment effect. This was further supported by Cox regression analysis: the risk of subsequent uterine cancer was significantly increased in women receiving hormonal therapy compared with those not receiving it, with a hazard ratio of 2.97 (95% CI 1.84-4.80).

Place, publisher, year, edition, pages
2008. Vol. 99, no 4, 611-5 p.
Keyword [en]
breast carcinoma in situ, second cancers, hormonal therapy, uterine cancer
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-89246DOI: 10.1038/sj.bjc.6604524PubMedID: 18665169OAI: oai:DiVA.org:uu-89246DiVA: diva2:159733
Available from: 2009-02-10 Created: 2009-02-10 Last updated: 2009-03-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Endocrine Surgery
In the same journal
British Journal of Cancer
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 142 hits
ReferencesLink to record
Permanent link

Direct link