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Short-term outcome predictors in infants born at 23-24 gestational weeks
Dept. of Paediatrics, Helsingborg Hospital, Sweden.
Centre of Repro Epi, Tomblad Institute, Lund University, Sweden.
Dept of Obstet and Gyn, University Hospital, Lund, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnneurologisk forskning/Ahlsten)
2008 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 97, no 5, 551-556 p.Article in journal (Refereed) Published
Abstract [en]

AIM: Outcome is uncertain in infants born at 23-24 gestational weeks. The aim of the present study was to identify possible early predictors of outcome in these infants. MATERIALS AND METHODS: Data from the Swedish medical birth register (MBR) for live-born infants with gestational ages (GAs) 23 and 24 weeks, born during the time-period 2000-2002, were analysed in relation to short-term outcomes, that is survival and survival without severe brain damage (intraventricular haemorrhage [IVH] grades 3 and 4 and/or periventricular leukomalacia [PVL]). RESULTS: In 57 infants born at 23 gestational weeks, survival was associated with birthweight (BW) (p = 0.018) and 5-min Apgar score (p = 0.020) on univariate analyses. In 99 infants born at 24 weeks of gestation, survival without severe brain damage correlated with BW (p = 0.039), birth type (singleton/multiple) (p = 0.017) and Apgar score at 1, 5 and 10 min (p = 0.028, 0.014 and 0.030, respectively). The best model for predicting survival without severe brain damage in infants born at 24 gestational weeks was based on 5-min Apgar score and birth type. The small number of live-born infants at 23 weeks of gestation did not allow for multiple logistic regression analyses. CONCLUSION: The 5-min Apgar score is associated with short-term outcome in live-born infants at 23-24 gestational weeks. The association is stronger for infants born at 24 weeks of gestation.

Place, publisher, year, edition, pages
2008. Vol. 97, no 5, 551-556 p.
Keyword [en]
Apgar score, outcome, preterm, prognosis, survival
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-89271DOI: 10.1111/j.1651-2227.2008.00737.xISI: 000254988600009PubMedID: 18394098OAI: oai:DiVA.org:uu-89271DiVA: diva2:159827
Available from: 2009-02-10 Created: 2009-02-10 Last updated: 2017-12-14Bibliographically approved

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