uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Design of Class Structures and Inter Class Communication Interface: Computer Methods used in Non-linear Mixed Effects Modeling
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
2008 (English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The field of pharmacokinetics and pharmacodynamics describes the interactionbetween drugs and the human body from the time the drug is absorbed in the blood stream, distributed in the body, metabolized and finally excreted. The behavior can be described with nonlinear mixed effects models. NONMEM is a software for estimating parameters of such models and simulation of data. This thesis describes the design of Perl-speaks-NONMEM (PsN) which is a software framework for control of different aspects of NONMEM such as creating input, performing execution and output interpretation and presentation. The framework aims to simplify implementation of a range of statistical tools not featured in NONMEM. PsN includes the Bootstrap for measuring statistical accuracy and precision, the Case Deletion Diagnostics (CDD) for identifying influential individuals in medical studies and the Log Likelihood Profiling (LLP) for estimating asymmetrical confidence intervals for parameter estimates. PsN interfaces with various GRID systems: Sun Grid Engine, Plattform LSF and openMosix to enable parallel execution of NONMEM instances. The implementation of PsN was aided with custom built tools for generating class definitions, constructors and from UML diagrams. PsN also provides a set of command line interface tools that simplify usage for researchers without programming experience.

Place, publisher, year, edition, pages
2008.
Series
IT ; 08 004
Identifiers
URN: urn:nbn:se:uu:diva-89279OAI: oai:DiVA.org:uu-89279DiVA, id: diva2:159881
Presentation
(English)
Uppsok
Technology
Supervisors
Examiners
Available from: 2009-02-12 Created: 2009-02-10 Last updated: 2009-11-19Bibliographically approved

Open Access in DiVA

fulltext(1720 kB)732 downloads
File information
File name FULLTEXT01.pdfFile size 1720 kBChecksum SHA-512
efbc6eca5484ff79b84bc23dbf3d091f1d153b7191e0a108b12a30acf0d9b5bab1a1b3d9440f71aacde6b50a18100df89ade3308d35d63224132946ca30ddf8a
Type fulltextMimetype application/pdf

By organisation
Department of Information Technology

Search outside of DiVA

GoogleGoogle Scholar
Total: 732 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 739 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf