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Organochlorines and bone: Effects of organochlorines on bone tissue morphology, composition and strength
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolutionary Biology.ORCID iD: 0000-0002-8949-3555
2000 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

From results presented during the last decade, it is obvious that the skeleton is a targetorgan for a number of persistent organochlorines. So far, however, little attention hasbeen paid to this subject.

This thesis examines the effects of one such compound, the ubiquitous PCB-congener, 3,3',4,4',5-pentachlorobiphenyl (PCB126), on rat bone morphology, composition and strength. The impact of a cocktail of persistent organic pollutants (POPs) on bone mineral density in Baltic grey seal and in a small population of Swedish males was also studied.

It was found that PCB 126 induced profound alterations in the long bones of the rat;including increased cortical thickness, increased trabecular mineral density, decreasedmarrow cavity, decreased collagen content, structural changes of the collagen molecule and impairment of mechanical characteristics, such as decreased maximum torqueand decreased stiffness. The mechanisms underlaying these effects are not known, butthe effects obtained cannot be explained either by changes in vitamin C and vitamin Alevels, or by disturbances of the sex endocrine system.

By peripheral quantitative computed tomography (pQCT) of grey seal bone specimens, thissis also shows that mineral density of trabecular bone was reduced, as in human osteoporosis, during the period of maximum PCB and DDT contamination of the Baltic (1965 - 1985).

An epidemiological study on Swedish males indicated a negative relation between bonemineral density and blood levels of the DDT metabolite p,p'-DDE. This implies the possibility that organochlorines may act as skeleto-toxic agents in humans, even at low exposure levels.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2000. , 63 p.
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1104-232X ; 528
Keyword [en]
Developmental biology
Keyword [sv]
Utvecklingsbiologi
National Category
Developmental Biology
Research subject
Ecotoxicology
Identifiers
URN: urn:nbn:se:uu:diva-1049ISBN: 91-554-4701-5 (print)OAI: oai:DiVA.org:uu-1049DiVA: diva2:160587
Public defence
2000-05-12, Föreläsningsalen, Norbyvägen 18A vid EBC, Uppsala, Uppsala, 13:15
Available from: 2000-04-21 Created: 2000-04-21 Last updated: 2017-01-02Bibliographically approved

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