First cyclotide from Hybanthus (Violaceae)
2001 (English)In: Phytochemistry, ISSN 0031-9422, E-ISSN 1873-3700, Vol. 58, no 1, 47-51 p.Article in journal (Refereed) Published
Hypa A, a novel macrocyclic polypeptide containing 30 amino acid residues, has been isolated from the n-butanol extract of the Argentine plant Hybanthus parviflorus. The sequence, cyclo-(SCVYIPCTITALLGCSCKNKVCYNGIPCAE), was determined by automated Edman degradation, quantitative amino acid analysis and nanospray MS/MS(2). Three intramolecular disulfide bridges stabilize the cyclic peptide backbone of hypa A. Using these structural features to classify the peptide as a cyclotide, we extended the distribution of that substance class to a new genus, and now propose a uniform nomenclature for cyclotides.
Place, publisher, year, edition, pages
2001. Vol. 58, no 1, 47-51 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-89793DOI: 10.1016/S0031-9422(01)00173-XPubMedID: 11524112OAI: oai:DiVA.org:uu-89793DiVA: diva2:161547