Nitro-L-arginine methyl ester: a potential protector against gentamicin ototoxicity
2005 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 125, no 10, 1033-8 p.Article in journal (Refereed) Published
The nitric oxide (NO) inhibitor nitro-L-arginine methyl ester (L-NAME) may act as an otoprotectant against high-frequency hearing loss caused by gentamicin, but further studies are needed to confirm this.Aminoglycoside antibiotics are still widely used by virtue of their efficacy and low cost. Their ototoxicity is a serious health problem and, as their ototoxic mechanism involves the production of NO, we need to assess the use of NO inhibitors for the prevention of aminoglycoside-induced sensorineural hearing loss. In this experimental study we used 30 Sprague-Dawley rats, 27 of which had gentamicin instilled into the middle ear. The otoprotectant L-NAME was administered topically to 12/27 animals. Its effect was determined in terms of attenuation of hearing loss, measured by shifts in the auditory brainstem response threshold. L-NAME reduced gentamicin-induced hearing loss in the high-frequency range, but gave no protection in the middle or low frequencies.
Place, publisher, year, edition, pages
2005. Vol. 125, no 10, 1033-8 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-89799DOI: 10.1080/00016480510038022PubMedID: 16298782OAI: oai:DiVA.org:uu-89799DiVA: diva2:161563