uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Complement activation on a model biomaterial surface: Binding of C3b via the alternative pathway amplification loop to plasma proteins adsorbed to the surface
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Manuscript (Other academic)
URN: urn:nbn:se:uu:diva-90375OAI: oai:DiVA.org:uu-90375DiVA: diva2:162706
Available from: 2003-04-24 Created: 2003-04-24 Last updated: 2010-01-13Bibliographically approved
In thesis
1. Complement Activation Triggered by Biomaterial Surfaces: Mechanisms and Regulation
Open this publication in new window or tab >>Complement Activation Triggered by Biomaterial Surfaces: Mechanisms and Regulation
2003 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Today there are a vast number of medical devices in temporary or permanent contact with human tissues. Blood-biomaterial contact is known to trigger the complement system and results in generation of fluid phase anaphylatoxins C3a and C5a, and surface-bound C3b and iC3b. All these products together are able to attract and activate leukocytes and trigger release of inflammatory mediators leading to a systemic inflammation indirectly causing hemostatic problems and even organ failure. The aim of this study was to identify how complement is triggered on a biomaterial surface and to find ways to regulate this activation.

The finding that complement activation on biomaterials can be divided into initiation and amplification will facilitate regulation of complement activation biomaterial surfaces. This concept is also compatible with the two techniques to regulate complement activation on a surface.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2003. 45 p.
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1253
Immunology, Biomaterials, Biocompatibility, Blood, Complement, Immunologi
National Category
Immunology in the medical area
Research subject
Clinical Immunology
urn:nbn:se:uu:diva-3410 (URN)91-554-5610-3 (ISBN)
Public defence
2003-05-20, Rudbeckssalen, Rudbeck Laboratory, Uppsala, 09:15
Available from: 2003-04-24 Created: 2003-04-24Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Oncology, Radiology and Clinical Immunology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 192 hits
ReferencesLink to record
Permanent link

Direct link