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Binding of a model regulator of complement activation (RCA) to a biomaterial surface: surface-bound factor H inhibits complement activation
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
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2001 In: Biomaterials, ISSN 0142-9612, Vol. 22, no 17, 2435-2443 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2001. Vol. 22, no 17, 2435-2443 p.
Identifiers
URN: urn:nbn:se:uu:diva-90377OAI: oai:DiVA.org:uu-90377DiVA: diva2:162708
Available from: 2003-04-24 Created: 2003-04-24Bibliographically approved
In thesis
1. Complement Activation Triggered by Biomaterial Surfaces: Mechanisms and Regulation
Open this publication in new window or tab >>Complement Activation Triggered by Biomaterial Surfaces: Mechanisms and Regulation
2003 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Today there are a vast number of medical devices in temporary or permanent contact with human tissues. Blood-biomaterial contact is known to trigger the complement system and results in generation of fluid phase anaphylatoxins C3a and C5a, and surface-bound C3b and iC3b. All these products together are able to attract and activate leukocytes and trigger release of inflammatory mediators leading to a systemic inflammation indirectly causing hemostatic problems and even organ failure. The aim of this study was to identify how complement is triggered on a biomaterial surface and to find ways to regulate this activation.

The finding that complement activation on biomaterials can be divided into initiation and amplification will facilitate regulation of complement activation biomaterial surfaces. This concept is also compatible with the two techniques to regulate complement activation on a surface.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2003. 45 p.
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1253
Keyword
Immunology, Biomaterials, Biocompatibility, Blood, Complement, Immunologi
National Category
Immunology in the medical area
Research subject
Clinical Immunology
Identifiers
urn:nbn:se:uu:diva-3410 (URN)91-554-5610-3 (ISBN)
Public defence
2003-05-20, Rudbeckssalen, Rudbeck Laboratory, Uppsala, 09:15
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Available from: 2003-04-24 Created: 2003-04-24Bibliographically approved

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