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Endothelial vasodilatory function is predicted by circulating apolipoprotein B and HDL in healthy humans
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och intermedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och intermedicin)
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2002 (English)In: Lipids, ISSN 0024-4201, E-ISSN 1558-9307, Vol. 37, no 12, 1135-1140 p.Article in journal (Refereed) Published
Abstract [en]

Endothelium-dependent vasodilation (EDV), LDL particle size, and antibodies against oxidized LDL (oxLDLab) have been shown to be related to the development of atherosclerosis and cardiovascular disease. In this study, we investigated whether LDL particle size, oxLDLab, apolipoproteins, and lipoproteins are related to endothelial vasodilatory function in a population sample of 58 apparently healthy subjects aged 20 to 69 yr. EDV and endothelium-independent vasodilation (EIDV) were studied in the forearm during local administration of methacholine chloride (2 and 4 microg/min) or sodium nitroprusside (5 and 10 microg/min). Forearm blood flow was determined with venous occlusion plethysmography. In multiple stepwise regression analyses, neither oxLDLab nor small LDL particles were significantly predictive of endothelial vasodilatory function. Instead, a high level of apolipoprotein B (apoB) was an independent predictor of both attenuated EDV and EIDV (r = -0.43, P < 0.01, and r = -0.34, P < 0.05, respectively). HDL cholesterol, on the other hand, was the only lipid variable that was significantly related to the EDV to EIDV ratio, an index of endothelial vasodilatory function (r = 0.35, P < 0.01). The inverse associations between apoB and both EDV and EIDV indicate that apoB might be an early marker of structural vascular changes in healthy subjects, whereas HDL seems to be more specifically related to endothelial vasodilatory function.

Place, publisher, year, edition, pages
2002. Vol. 37, no 12, 1135-1140 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-90409DOI: 10.1007/s11745-002-1010-3PubMedID: 12617465OAI: oai:DiVA.org:uu-90409DiVA: diva2:162753
Available from: 2003-05-06 Created: 2003-05-06 Last updated: 2010-10-21Bibliographically approved
In thesis
1. Lipids and Endothelium-Dependent Vasodilation
Open this publication in new window or tab >>Lipids and Endothelium-Dependent Vasodilation
2003 (English)Doctoral thesis, comprehensive summary (Other academic)
Alternative title[sv]
Lipider och endotelberoende vasodilatation
Abstract [en]

Impaired endothelium-dependent vasodilation (EDV) is associated with atherosclerotic cardiovascular disease as well as several of its risk factors.

The aim of the present thesis was to investigate how lipids influence EDV in the vascular bed of the human forearm.

Apolipoprotein B was inversely associated with both EDV and endothelium-independent vasodilation (EIDV) in healthy subjects aged 20-69 years. HDL cholesterol was associated with the EDV to EIDV ratio (EFI). Small LDL particles and antibodies against oxidized LDL were not associated with endothelial vasodilatory function.

The EFI in young, healthy subjects was positively associated with alpha-linolenic acid proportion, but inversely associated with myristic acid in men only. Eicosapentaenoic acid was positively associated with EDV, whereas dihomo-gamma-linolenic acid was inversely associated with both EDV and EIDV in men.

Acute elevation of long-chain fatty acids with Intralipid®/heparin infusion in young, healthy subjects impaired EDV after 2 h. This impairment could be prevented by co-infusing vitamin C, diclophenac or L-arginine. Acute elevation of both medium-chain and long-chain fatty acids during Structolipid®/heparin infusion did not impair EDV.

An ordinary meal (34 E% fat) transiently attenuated EDV at 1 hour. No attenuation in EDV was observed after meals containing 20 and 3 E% fat.

These findings show that the endothelial vasodilatory function is associated with fatty acid profile in serum in the fasting state and during acute fatty acid elevation, as well as with apolipoprotein B and HDL cholesterol. Furthermore, lowering dietary fat content to 20 E% or less preserves endothelial vasodilatory function and might therefore protect against atherosclerosis.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2003. 78 p.
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1263
Keyword
Medicine, Atherosclerosis, endothelium, vasodilation, nitric oxide, fatty acid, meal, diet, lipoprotein, cyclooxygenase, diclophenac, L-arginine, LDL, human, Medicin
National Category
Dermatology and Venereal Diseases
Research subject
Internal Medicine
Identifiers
urn:nbn:se:uu:diva-3424 (URN)91-554-5633-2 (ISBN)
Public defence
2003-05-26, Aulan, Thoraxhuset - ingång 50, Akademiska sjukhuset, Uppsala, 09:15
Opponent
Supervisors
Available from: 2003-05-06 Created: 2003-05-06 Last updated: 2010-10-21Bibliographically approved

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Steer, PeterBasu, SamarVessby, BengtLind, Lars

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