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Author:
Bredenberg, Susanne (Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmacy)
Title:
New Concepts in Administration of Drugs in Tablet Form: Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System
Department:
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmacy
Responsible org.:
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmacy
Publication type:
Doctoral thesis, comprehensive summary (Other academic)
Language:
English
Place of publ.: Uppsala Publisher: Acta Universitatis Upsaliensis
Pages:
83
Series:
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, ISSN 0282-7484; 287
Year of publ.:
2003
URI:
urn:nbn:se:uu:diva-3433
Permanent link:
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3433
ISBN:
91-554-5600-6
Subject category:
Pharmaceutical Sciences
SVEP category:
Pharmaceutics
Research subject:
Pharmaceutics
Keywords(en) :
Pharmaceutics, Interactive mixture, Dose homogeneity, Disintegration, Bioadhesion, Oromucosal delivery, Sublingual tablet, Rapid absorption, Individual dosage, Drug dispensing device
Keywords(sv) :
Galenisk farmaci
Abstract(en) :

This thesis presents two new concepts in oral drug administration and the results of evaluation of some relevant formulation factors.

Investigation into improving the homogeneity of mixtures for tableting indicated that it may be possible to obtain interactive dry mixtures of micronised drugs containing drug proportions as low as 0.015% w/w. By studying the relationship between disintegration time and tensile strength, it was found that the microstructure surrounding the disintegrant particles may influence the disintegration process. Therefore, avoidance of excipients which are highly deformable or very soluble in water will result in more rapid disintegration. Further, it is possible to increase the bioadhesive properties of a non-bioadhesive carrier material by forming interactive mixtures containing a fine particulate bioadhesive material.

The new sublingual tablet concept presented is based on interactive mixtures consisting of a water-soluble carrier covered with fine drug particles and a bioadhesive component. With this approach, it is possible to obtain rapid dissolution in combination with bioadhesive retention of the drug in the oral cavity. Clinical data indicate that this allows rapid sublingual absorption while simultaneously avoiding intestinal absorption.

An individualised dose administration system is also presented. This system is based on the use of standardised units (microtablets), each containing a sub-therapeutic amount of the active ingredient. The required dose is fine-tuned by electronically counting out a specific number of these units using an automatic dose dispenser. A patient handling study supported the suggestion that the dosage of some medications can be more easily and safely individualised for each patient with this method than by using traditional methods of mixing different standard tablet strengths or dividing tablets.

Public defence:
2003-05-15, B21, BMC, Uppsala, 13:15
Degree:
degree of Doctor of Philosophy (Faculty of Pharmacy)
Supervisor:
Nyström, Christer, Professor
Opponent:
Caramella, Carla, Professor (Pharmaceutical Chemistry, University Pavia, Pavia)
Available from:
2003-04-23
Created:
2003-04-23
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