uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Renal function after autologous bone marrow transplantation in children: a long-term prospective study
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
2002 In: Bone Marrow Transplantation, ISSN 0268-3369, Vol. 29, no 2, 129-136 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2002. Vol. 29, no 2, 129-136 p.
Identifiers
URN: urn:nbn:se:uu:diva-90959OAI: oai:DiVA.org:uu-90959DiVA: diva2:163500
Available from: 2003-10-30 Created: 2003-10-30Bibliographically approved
In thesis
1. Late Effects After Autologous Bone Marrow Transplantation in Childhood
Open this publication in new window or tab >>Late Effects After Autologous Bone Marrow Transplantation in Childhood
2003 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Fifty children with hematologic malignancies have been treated with autologous BMT in Uppsala. The aim was to describe late effects in this group with special reference to cataracts, reduced final height, and to hepatic, renal, and pulmonary late effects.

Cataracts: All patients who received TBI in their conditioning developed posterior subcapsular cataract after BMT. A few patients with visual impairment affecting daily life needed cataract surgery, whereas the visual acuity was well preserved in most of the other patients.

Final height: There was a decrease in final height relative both to height at BMT and to target height. This decrease was significant both in those who had received TBI only and in those who had been given cranial irradiation. Cranial irradiation, young age at BMT, and short duration of GH treatment were predictors of height loss.

Hepatic function: Hepatic function was well preserved over a period of 10 years after BMT. TBI did not appear to be a risk factor for hepatic impairment.

Renal function: Six months after BMT there was a decrease in renal function in patients who had received TBI. It then recovered, albeit incompletely, and stabilized. After the first year there was little change over a period of 10 years after BMT. TBI appeared to be the most important risk factor for the development of chronic renal impairment in a number of patients. Nephrotoxic antibiotics may have contributed.

Pulmonary function: Six months after BMT there was a decrease in pulmonary function in those who received TBI. It then recovered and stabilized at the pretransplant level. After the first year there was little change over a period of 10 years after BMT. TBI appeared to be the most important risk factor for restrictive pulmonary disease in a number of patients whereas chemotherapy might also have been of importance for impaired gas exchange.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2003. 63 p.
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1293
Keyword
Pediatrics, bone marrow transplantation, children, follow-up, cataracts, final height, pubertal development, hepatic function, renal function, pulmonary function, Pediatrik
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-3673 (URN)91-554-5767-3 (ISBN)
Public defence
2003-11-21, Rosénsalen, Akademiska barnsjukhuset, 751 85 Uppsala, 09:15
Opponent
Supervisors
Available from: 2003-10-30 Created: 2003-10-30Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Women's and Children's Health

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 353 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf