uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The importance of monocyte and granulocyte activation in rheumatoid arthritis and primary Sjögren's syndrome
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
1999 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Macrophages and neutrophils infiltrate the synovium and synovial fluid in rheumatoid arthritis (RA). These cells are considered to contribute to the destructive process in RA.

The expression of adhesion and phagocytosis receptors on the surface of peripheral granulocytes and monocytes was increased in patients with RA. Elevation of the serum concentration of the mononuclear and the neutrophil derived granula proteins lysozyme and MPO and not of the neutrophil derived proteins HNL and lactoferrin suggest a stimulated activity of mononuclear phagocytes in RA. Measurement ofserum lysozyme, as a potential indicator of monocyte/macrophage activity, might beof clinical value in studies of the disease activity in RA.

Low dose prednisolone treatment decreased the activation level of monocytes and eosinophils but only had minor effects on peripheral blood neutrophils. Patients with RA were treated with metyrapone in order to lower the concentration of the endogenous cortisol. This lowering of endogenous cortisol level had minor impact onmonocyte and eosinophil expression of adhesion receptors.

C-reactive protein (CRP) stimulated the granulocyte respiratory burst induced by E.coli and PMA, and the granulocyte phagocytosis of opsonized and non-opsonized E.coli. Granulocyte adhesion to E-selectin and neutrophil expression of CD44 (p =  0.058) were decreased by CRP. The neutrophil expression of the receptor antigen CD11b (p < 0.05) was increased by CRP.

The adhesion of peripheral blood neutrophils and eosinophils was enhanced in primary Sjögren's syndrome (pSS). Accordingly results from earlier studies of impaired neutrophil adhesion in pSS were not confirmed.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 1999. , 60 p.
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 869
Keyword [en]
Medical sciences, Rheumatoid arthritis, primary Sjögren's syndrome, peripheral blood, monocyte, macrophage, neutrophil, eosinophil, adhesion, phagocytosis, respiratory burst, CRP
Keyword [sv]
National Category
Medical and Health Sciences
Research subject
Clinical Chemistry
URN: urn:nbn:se:uu:diva-375ISBN: 91-554-4554-3OAI: oai:DiVA.org:uu-375DiVA: diva2:163576
Public defence
1999-11-04, Skoogsalen, ingång 78/79, Akademiska sjukhuset, Uppsala, Uppsala, 09:15
Available from: 1999-10-14 Created: 1999-10-14Bibliographically approved

Open Access in DiVA

No full text
Buy this publication >>

By organisation
Department of Medical Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 61 hits
ReferencesLink to record
Permanent link

Direct link