Rapid Microwave Promoted Sonogashira Coupling Reactions on Solid Phase
2003 (English)In: Journal of Organic Chemistry, Vol. 68, no 16, 6431-6434 p.Article in journal (Refereed) Published
A microwave-enhanced, rapid, and efficient solidphase version of the Sonogashira reaction is presented. It has been applied to the coupling of aryl iodides and bromides with various acetylene derivatives giving excellent yields in 15 to 25 min. The scopes of homogeneous, solventless, and solid-phase conditions for Sonogashira coupling of aryl halides are compared.
Place, publisher, year, edition, pages
2003. Vol. 68, no 16, 6431-6434 p.
IdentifiersURN: urn:nbn:se:uu:diva-91464DOI: 10.1021/jo034284sOAI: oai:DiVA.org:uu-91464DiVA: diva2:164201