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Inferring the α-proteobacterial ancestor
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Department of Evolution, Genomics and Systematics, Molecular Evolution.
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In: Proc Natl Acad Sci USAArticle in journal (Refereed) Submitted
Identifiers
URN: urn:nbn:se:uu:diva-91601OAI: oai:DiVA.org:uu-91601DiVA: diva2:164392
Available from: 2004-04-13 Created: 2004-04-13Bibliographically approved
In thesis
1. Mitochondrial Evolution: Turning Bugs into Features
Open this publication in new window or tab >>Mitochondrial Evolution: Turning Bugs into Features
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The bacterial origin of mitochondria from an ancient endosymbiosis is now widely accepted and the mitochondrial ancestor is generally believed to belong to the bacterial subdivision α-proteobacteria. The high fraction of mitochondrial proteins encoded in the nucleus has commonly been explained with a massive transfer of genes from the genome of the ancestral mitochondrion.

The aim of this work was to get a better understanding of the mitochondrial origin and evolution by comparative genomics and phylogenetic analyses on mitochondria and α-proteobacteria. To this end, we sequenced the genomes of the intracellular parasites Bartonella henselae and Bartonella quintana, the causative agents of cat-scratch disease and trench fever, and compared them with other α-proteobacteria as well as mitochondrial eukaryotes.

Our results suggest that the adaptation to an intracellular life-style is coupled to an increased rate of genome degradation and a reduced ability to accommodate environmental changes. Reconstruction of the α-proteobacterial ancestor and phylogenetic analyses of the mitochondrial proteome in yeast revealed that only a small fraction of the proteins used for mitochondrial functions could be traced to the α-proteobacteria. Furthermore, a substantial fraction of the mitochondrial proteins was of eukaryotic origin and while most of the genes of the α-proteobacterial ancestor have been lost, many of those that have been transferred to the nuclear genome seem to encode non-mitochondrial proteins.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2004. 37 p.
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1104-232X ; 961
Keyword
Biology, Biologi
National Category
Biological Sciences
Identifiers
urn:nbn:se:uu:diva-4216 (URN)91-554-5933-1 (ISBN)
Public defence
2004-05-14, Ekmansalen, Kärnhuset, EBC, Uppsala, 13:15
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Available from: 2004-04-13 Created: 2004-04-13Bibliographically approved

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