Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemiaShow others and affiliations
2021 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 195, no 1, p. 119-122Article in journal (Refereed) Published
Abstract [en]
Infants with acute lymphoblastic leukaemia (ALL) have a high frequency of central nervous system (CNS) involvement. Flow cytometric analysis of cerebrospinal fluid (CSF) was recently demonstrated to be a sensitive method for detecting CNS involvement in childhood ALL. In the present study, CSF from 14 infants was collected at routine lumbar punctures and analysed by multicolour flow cytometry. At initial diagnosis, leukaemic blasts were detected in CSF by flow cytometry in 11 patients (78 center dot 6%) compared to seven patients (50%) by cytospin. Larger studies are needed to determine if CSF flow cytometry has prognostic value in infant ALL.
Place, publisher, year, edition, pages
WILEY John Wiley & Sons, 2021. Vol. 195, no 1, p. 119-122
Keywords [en]
ALL, childhood, flow cytometry, metastasis, central nervous system, cerebrospinal fluid
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-469873DOI: 10.1111/bjh.17769ISI: 000684953100001PubMedID: 34396501OAI: oai:DiVA.org:uu-469873DiVA, id: diva2:1645629
2022-03-182022-03-182024-01-15Bibliographically approved