Antithrombin reduction after experimental cardiopulmonary resuscitation
2003 (English)In: Resuscitation, ISSN 0300-9572, E-ISSN 1873-1570, Vol. 59, no 2, 229-236 p.Article in journal (Refereed) Published
OBJECTIVE: To determine whether activation of coagulation and inflammation during cardiac arrest results in a reduction of antithrombin (AT) and an increase in thrombin-antithrombin (TAT) complex during reperfusion.
METHODS: Ventricular fibrillation (VF) was induced in ten anaesthetized pigs. After a 5-min non-intervention interval, closed-chest cardiopulmonary resuscitation (CPR) was performed for 9 min before defibrillation was attempted. If restoration of spontaneous circulation (ROSC) was achieved, the animals were observed for 4 h and repeated blood samples were taken for assay of AT, TAT and eicosanoids (8-iso-PGF(2alpha) and 15-keto-dihydro-PGF(2alpha)).
RESULTS: AT began to decrease 15 min after ROSC and the reduction continued throughout the observation period (P<0.05). The lowest mean value (79%) occurred 60 min after ROSC. The TAT level was increased during the first 3 h after ROSC (P<0.05), indicating thrombin generation. The eicosanoids were increased throughout the observation period (P<0.05).
CONCLUSIONS: AT is reduced and TAT and eicosanoids are increased after cardiac arrest, indicating activation of coagulation and inflammation.
Place, publisher, year, edition, pages
2003. Vol. 59, no 2, 229-236 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-91830DOI: 10.1016/S0300-9572(03)00182-5PubMedID: 14625115OAI: oai:DiVA.org:uu-91830DiVA: diva2:164687