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Factors associated with the development of abdominal aortic aneurysm. A study based on historical- and cross-sectional screening data
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
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(English)Article in journal (Refereed) Submitted
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-91972OAI: oai:DiVA.org:uu-91972DiVA: diva2:164894
Available from: 2004-09-01 Created: 2004-09-01 Last updated: 2013-08-14Bibliographically approved
In thesis
1. Abdominal Aortic Aneurysm: Experience from a Screening Study in Northern Sweden
Open this publication in new window or tab >>Abdominal Aortic Aneurysm: Experience from a Screening Study in Northern Sweden
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Abdominal aortic aneurysm (AAA) is a common problem with life-threatening consequences and was suspected to be a serious health problem in Norsjö, a municipality in northern Sweden. A screening study was undertaken to investigate the prevalence, risk factors associated with AAA and the effect of screening on quality of life (QoL). All men and women, aged 65-75 years, were invited to an ultrasonography (US) examination, 91% attended and 92 subjects were also evaluated with computed tomography (CT).

Depending on diagnostic criteria, the AAA prevalence was 3.6-16.9% in men and 0.8-9.4% in women. Seventy-five percent of the differences between US- and CT anteroposterior measurements were less than 5 mm. A decrease in mental health was observed among AAA patients with low baseline SF-36 scale scores. Elevated cholesterol at age 60 years were associated with screening detected AAA after 12 years of follow-up. Smoking, atherosclerosis and having a first degree relative with AAA were associated with AAA at screening. Compared to blood samples obtained 12 years prior to screening an elevation of hsCRP over time was observed among AAA patients.

Based on a systematic review of the literature, different screening strategies were analysed in a Markov cohort model. The cost per life year gained ranged from $8 309 to $14 084 and was estimated to $10 474 when 65 year old men were screened once.

Conclusions: The highest prevalence of AAA ever reported, in a population-based screening program, was found in Norsjö. The risk of having an AAA at screening showed a strong but complex association with atherosclerosis and its risk factors, genetic and inflammatory mechanisms may also be important. Screening 65-year-old men for AAA may be cost-effective, but QoL aspects on the cost-effectiveness of AAA screening merits further investigation.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2004. 96 p.
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1364
Surgery, abdominal aortic aneurysm, definition, prevalence, ultrasonography, computed tomography, variability, quality of life, SF-36, risk factor, cholesterol, smoking, CRP, heredity, atherosclerosis, screening, cost-effectiveness, cost-utility, Kirurgi
National Category
urn:nbn:se:uu:diva-4459 (URN)91-554-6008-9 (ISBN)
Public defence
2004-09-24, Auditorium Minus, Museum Gustavianum, Uppsala, 13:15
Available from: 2004-09-01 Created: 2004-09-01Bibliographically approved

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Wanhainen, AndersBergqvist, DavidBjörck, Martin
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