uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Migraine in women: Epidemiological, clinical, genetic, and experimental aspects
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
2000 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Migraine is a significant public-health problem. Few studies have focused on migraine inmiddle-aged and older women in the general population. The primary aim of this study was tocharacterise migraine, to analyse how migraine changes with age, and to test hypotheses aboutsome factors possibly relevant to the aetiology and pathophysiology of migraine.

Women aged 40-74 years in Uppsala County are invited regularly to a mammographyscreening program (MSP). The lifetime prevalence and the one-year prevalence of migraineheadache in a sample (n = 728) of women attending the MSP was 31% and 18%, respectively.The one-year prevalence of migraine headache declined with age, by approximately 50% perdecade. The decline was accompanied by a decrease in pain intensity, suggesting a causalrelationship. Hormonal replacement therapy was not a significant factor for migraineheadache. The prevalence of transient visual disturbances (TVDs) resembling migraine auraswas 13% in women attending the MSP. The characteristics of these TVDs were the same as infemale migraine patients, suggesting that TVDs are migraine phenomena. Deficientmetabolism due to mutations in the genes of the xenobiotic metabolising enzymes cytochromeP450 2D6 and glutathione S-transferase M1 was not deemed to be important in the aetiologyof migraine. Eight per cent of women who ingested a glass of ice-cold water experienced amomentary headache. Women who experienced one or more migraine headache attacks in theprevious year (active migraine headache) were twice as likely to experience a headacheinduced by the cold water as non-migrainous women. This indicates that migraine and cold induced headache have a common pathogenetic mechanism.

To conclude, migraine phenomena are common in middle-aged and older women. Migraineheadache disappears with age, probably because the intensity decreases. Active migraineheadache facilitates the perception of forehead pain caused by the ingestion of cold water.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2000. , 53 p.
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 924
Keyword [en]
Neurosciences, Migraine, aura, prevalence, age, CYP2D6, GSTM1, cold induced headache
Keyword [sv]
Neurovetenskap
National Category
Neurology
Research subject
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-450ISBN: 91-554-4706-6 (print)OAI: oai:DiVA.org:uu-450DiVA: diva2:164965
Public defence
2000-05-05, Grönwallsalen, Akademiska sjukhuset, ingång 70, Uppsala, Uppsala, 13:15
Available from: 2000-04-14 Created: 2000-04-14Bibliographically approved

Open Access in DiVA

No full text
Buy this publication >>

By organisation
Department of Neuroscience
Neurology

Search outside of DiVA

GoogleGoogle Scholar

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
Total: 428 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf