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Deranged spontaneous behaviour and decrease in cholinergic muscarinic receptors in hippocampus in the adult rat, after neonatal exposure to the flame-retardant, 2,2',4,4',5-pentabromodiphenyl ether (PBDE 99).
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Evolutionary Biology, Department of Environmental Toxicology.
Article in journal (Refereed) Submitted
URN: urn:nbn:se:uu:diva-92205OAI: oai:DiVA.org:uu-92205DiVA: diva2:165192
Available from: 2004-10-06 Created: 2004-10-06Bibliographically approved
In thesis
1. Neonatal Developmental Neurotoxicity of Brominated Flame Retardants, the Polybrominated Diphenyl Ethers (PBDEs)
Open this publication in new window or tab >>Neonatal Developmental Neurotoxicity of Brominated Flame Retardants, the Polybrominated Diphenyl Ethers (PBDEs)
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis examines developmental neurotoxic effects of polybrominated diphenyl ethers (PBDEs), PBDE 99, PBDE 153, and the fully brominated PBDE 209, after exposure during the newborn period in rodents.

Our environment contains vast numbers of contaminants, including the flame retardants, PBDEs. The PBDEs are widely found in the environment and are increasing in human milk. Individuals can be exposed to PBDEs during their whole lifetime, and especially during the lactation period. The neonatal period, coinciding with the lactation period, is characterized in many mammalian species by rapid growth and development of the immature brain. It has been shown that numerous toxicants can induce permanent disorders in brain function when administered to the neonatal mouse during the brain growth spurt (BGS). In mice and rats this period is postnatal, spanning over the first 3-4 weeks of life, while in humans, BGS begins during the third trimester of pregnancy and continues throughout the first two years of life.

The present studies identified a defined critical period during BGS in mice when the brain is vulnerable to insults of low doses of PBDEs and that it is the presence of PBDEs or their metabolites in the brain during this critical period that is crucial to evoking neurotoxic effects. The effects observed are permanent altered spontaneous behavior, reduced habituation, deficits in learning and memory, and disturbances in the cholinergic system. These effects worsen with age.

The ability of PBDEs to induce neurotoxic effects does not appear to be gender-, strain- or species-specific, because the neurotoxic effects are induced in rats and male and female mice of different strains.

The developmental neurotoxic effects of PBDEs are similar to those observed for polychlorinated biphenyls (PCBs) and possible interactive effects of PBDEs and other environmental contaminants are therefore of concern.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2004. 62 p.
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1104-232X ; 1020
Biology, brominated flame retardants, polybrominated diphenyl ethers, PBDE, neonatal, development, neurotoxicity, behaviour, cholinergic system, Biologi
National Category
Biological Sciences
urn:nbn:se:uu:diva-4576 (URN)91-554-6053-4 (ISBN)
Public defence
2004-10-29, Lindahlsalen, EBC, Norbyvägen 18A, Uppsala, 09:00
Available from: 2004-10-06 Created: 2004-10-06 Last updated: 2011-02-09Bibliographically approved

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