Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats
2007 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 183, no 1-2, 33-42 p.Article in journal (Refereed) Published
Uptake of antigens and bacteria over the follicle-associated epithelium (FAE) is increased after chronic psychological stress. We investigated whether stress affects the immune response to particle-conjugated antigens taken up via the FAE. Rats were submitted to two 10-day periods of water avoidance stress and orally immunized during these periods. Stressed immunized rats displayed altered cell populations and a Th1-skewed immune response within the lymphoid follicles, together with enhanced delayed-type hypersensitivity. We conclude that chronic stress affects the cell-mediated immune response after oral immunization, which may have implications for the understanding of allergic and autoimmune diseases and development of oral vaccines.
Place, publisher, year, edition, pages
2007. Vol. 183, no 1-2, 33-42 p.
Administration; Oral, Animals, Antigens; CD8/metabolism, Antigens; Differentiation/metabolism, Chronic Disease, Cytokines/metabolism, Enzyme-Linked Immunosorbent Assay/methods, Flow Cytometry/methods, Gene Expression Regulation/physiology, Humans, Hypersensitivity; Delayed/etiology/immunology, Male, Peyer's Patches/immunology/metabolism, Rats, Rats; Wistar, Serum Albumin/administration & dosage/*immunology, Starch/*administration & dosage/immunology, Stress; Psychological/*immunology/pathology, Time Factors
Medical and Health Sciences Pharmaceutical Sciences
IdentifiersURN: urn:nbn:se:uu:diva-92411DOI: 10.1016/j.jneuroim.2006.11.005ISI: 000244773000005OAI: oai:DiVA.org:uu-92411DiVA: diva2:165474