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Plasma Hyaluronan Decreases During ICU Stay in COVID-19 Survivors but Not inNon-Survivor: A Retrospective Cohort Study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.ORCID iD: 0000-0002-4205-7131
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Uppsala Clinical Research Center (UCR). Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.ORCID iD: 0000-0003-1537-6740
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.ORCID iD: 0000-0002-1976-4129
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2021 (English)In: Biomarkers Journal, ISSN 2472-1646, Vol. 7, no 6, article id 94Article in journal (Refereed) Published
Abstract [en]

Plasma hyaluronan concentration is associated with disease severity in COVID-19 patients. Hyaluronan is found in secretions and alveolar exudate in COVID-19 patients, and increased perialveolar interstitial hyaluronan has been found in the lungs of COVID-19 patients. This may obstruct alveoli and impair gas exchange and thereby contribute to hypoxemia and respiratory failure. The aim of this study was to describe the dynamics of plasma hyaluronan concentrations and to compare hyaluronan concentrations between non-survivors and survivors in critically ill COVID-19 patients.
Place, publisher, year, edition, pages
2021. Vol. 7, no 6, article id 94
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Anesthesiology and Intensive Care
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URN: urn:nbn:se:uu:diva-474258OAI: oai:DiVA.org:uu-474258DiVA, id: diva2:1657464
Available from: 2022-05-11 Created: 2022-05-11 Last updated: 2022-06-08Bibliographically approved

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van der Heijden, JaapKolliopoulos, ConstantinosStattin, KarlFrithiof, RobertKamali-Moghaddam, MasoodLin, Chun-YuTenhunen, JyrkiHultström, MichaelHeldin, Paraskevi

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van der Heijden, JaapKolliopoulos, ConstantinosStattin, KarlLipcsey, MiklosFrithiof, RobertKamali-Moghaddam, MasoodLin, Chun-YuTenhunen, JyrkiHultström, MichaelHeldin, Paraskevi
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Anaesthesiology and Intensive CareDepartment of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLabUppsala Clinical Research Center (UCR)Department of Medical SciencesDepartment of Immunology, Genetics and PathologyClinical ChemistryDepartment of Surgical SciencesIntegrative Physiology
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