uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Widespread disruption of genomic imprinting in adult interspecies mouse (Mus) hybrids
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Animal Development and Genetics.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Animal Development and Genetics.
Show others and affiliations
2005 (English)In: Genesis, ISSN 1526-954X, E-ISSN 1526-968X, Vol. 43, no 3, 100-108 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 43, no 3, 100-108 p.
Keyword [en]
Animals, Chimera/*genetics/growth & development, DNA Methylation, Epigenesis; Genetic, Genomic Imprinting, Growth/genetics, Hybridization; Genetic, Mice/*genetics/growth & development, Mice; Congenic/genetics/growth & development, Mice; Inbred C3H, Mice; Inbred C57BL, Research Support; Non-U.S. Gov't
National Category
Developmental Biology
Identifiers
URN: urn:nbn:se:uu:diva-92603DOI: 10.1002/gene.20161PubMedID: 16145677OAI: oai:DiVA.org:uu-92603DiVA: diva2:165747
Available from: 2005-02-14 Created: 2005-02-14 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Growth and Behaviour: Epigenetic and Genetic Factors Involved in Hybrid Dysgenesis
Open this publication in new window or tab >>Growth and Behaviour: Epigenetic and Genetic Factors Involved in Hybrid Dysgenesis
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In mammals, the most frequently observed hybrid dysgenesis effects are growth disturbances and male sterility. Profound defects in placental development have been described and our work on hybrids in genus Mus has demonstrated putative hybrid dysgenesis effects that lead to defects in lipid homeostasis and maternal behavior. Interestingly, mammalian interspecies hybrids exhibit strong parent-of-origin effects in that offspring of reciprocal matings, even though genetically identical, frequently exhibit reciprocal phenotypes. Recent studies have provided strong link between epigenetic regulation and growth, behavior and placental development. Widespread disruption of genomic imprinting has been described in hybrids between closely related species of the genus Peromyscus. The studies presented in this thesis aim to investigate the effects of disrupted epigenetics states on altered growth, female infanticide and placental dysplasia observed in Mus hybrids. We showed that loss-of-imprinting (LOI) of a paternally expressed gene, Peg1, was correlated with increased body weight of F1 hybrids. Furthermore, we investigated whether LOI of Peg1 in F1 females would interfere with maternal behavior. A subset of F1 females indeed exhibited highly abnormal maternal behavior in that they rapidly attacked and killed the pups. By microarray hybridization, a large number of differentially expressed genes in the infanticidal females as compared to normally behaving females were identified. In addtion to Peg1 LOI, we studied allelic expression of numerous imprinted genes in adult Mus interspecies hybrids. In contrast to the study from Peromyscus, patterns of LOI were not consistent with a direct influence of altered expression levels of imprinted genes on growth. Finally, we investigated the allelic interaction between an X-linked locus and a paternally expressed gene, Peg3, in placental defects in Mus hybrids. This study further strengthened the notion that divergent genetic and epigenetic mechanisms may be involved in hybrid dysgenesis in diverse groups of mammals.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 51 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 11
Keyword
Developmental biology, Interspecies hybridization, hybrid dysgenesis effect, speciation, genomic imprinting, epigenetics, Utvecklingsbiologi
National Category
Developmental Biology
Identifiers
urn:nbn:se:uu:diva-4784 (URN)91-554-6147-6 (ISBN)
Public defence
2005-03-17, Lindahlsalen, Evolutionary Biology Centre, Norbyvägen 18A, Uppsala, 10:00 (English)
Opponent
Supervisors
Available from: 2005-02-14 Created: 2005-02-14 Last updated: 2009-04-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Fundele, Reinald

Search in DiVA

By author/editor
Fundele, Reinald
By organisation
Animal Development and Genetics
In the same journal
Genesis
Developmental Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 537 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf