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F2-isoprostane excretion rate and diurnal variation in human urine
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition Research.
1999 In: Prostaglandins Leukot Essent Fatty Acids, ISSN 0952-3278, Vol. 61, no 3, 203-205 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
1999. Vol. 61, no 3, 203-205 p.
Identifiers
URN: urn:nbn:se:uu:diva-92653OAI: oai:DiVA.org:uu-92653DiVA: diva2:165814
Available from: 2005-03-10 Created: 2005-03-10Bibliographically approved
In thesis
1. Prostaglandins and Isoprostanes in Relation to Risk Factors for Atherosclerosis: Role of Inflammation and Oxidative Stress
Open this publication in new window or tab >>Prostaglandins and Isoprostanes in Relation to Risk Factors for Atherosclerosis: Role of Inflammation and Oxidative Stress
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Inflammation and oxidative stress may be involved in atherogenesis. This thesis describes clinical studies of prostaglandin F (PGF), an inflammatory mediator, and the isoprostane 8-iso-PGF, a reliable indicator of oxidative stress, and cytokine-related inflammatory mediators and indicators in healthy subjects and in a population-based cohort of Swedish men.

PGF and 8-iso-PGF formation in healthy subjects varied considerably between days with a mean intra-individual coefficient of variation of 41 % and 42 %, respectively. A morning urine sample reflected the basal level of 8-iso-PGF formation as accurately as a 24-hour urine collection, and represents a more practical alternative to the 24-hour urine collection in clinical studies. PGF formation (as measured by urinary 15-keto-dihydro-PGF) was increased in patients with type 2 diabetes and in smokers independent of other cardiovascular risk factors. These results indicated an on-going cyclooxygenase (COX)-mediated inflammatory reaction related to these conditions. Further, an increased formation of isoprostanes (as measured by urinary 8-iso-PGF) was found in patients with type 2 diabetes and in smokers, indicating a high level of oxidative stress in these men. The smokers had also increased levels of the cytokine interleukin-6, indicating an on-going cytokine-related inflammatory reaction. The inflammatory indicators C-reactive protein and serum amyloid A were related to overweight but not independently associated to type 2 diabetes. High levels of serum selenium in middle-aged men predicted reduced formation of PGF and 8-iso-PGF 27 years later.

In summary, low-grade, chronic COX-mediated and possibly cytokine-related inflammation, and oxidative stress, seem to be joint features of type 2 diabetes and smoking, two major risk factors of atherosclerosis, in elderly men. Inflammation and oxidative stress may represent a possible common pathogenetic link between established risk factors for atherosclerosis and atherogenesis.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 82 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 9
Keyword
Public health, prostaglandin F2α, F2-isoprostane, interleukin-6, C-reactive protein, serum amyloid A, tocopherols, cardiovascular risk factors, variation, inflammation, oxidative stress, human, Folkhälsomedicin
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-4803 (URN)91-554-6156-5 (ISBN)
Public defence
2005-04-01, Auditorium Minus, Museum Gustavianum, Akademigatan 3, Uppsala, 09:15
Opponent
Supervisors
Available from: 2005-03-10 Created: 2005-03-10Bibliographically approved

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