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F2-isoprostane and prostaglandin F2α metabolite excretion rate and day to day variation in healthy humans
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition Research.
2001 In: Prostaglandins Leukot Essent Fatty Acids, ISSN 0952-3278, Vol. 65, no 2, 99-102 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2001. Vol. 65, no 2, 99-102 p.
Identifiers
URN: urn:nbn:se:uu:diva-92654OAI: oai:DiVA.org:uu-92654DiVA: diva2:165815
Available from: 2005-03-10 Created: 2005-03-10Bibliographically approved
In thesis
1. Prostaglandins and Isoprostanes in Relation to Risk Factors for Atherosclerosis: Role of Inflammation and Oxidative Stress
Open this publication in new window or tab >>Prostaglandins and Isoprostanes in Relation to Risk Factors for Atherosclerosis: Role of Inflammation and Oxidative Stress
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Inflammation and oxidative stress may be involved in atherogenesis. This thesis describes clinical studies of prostaglandin F (PGF), an inflammatory mediator, and the isoprostane 8-iso-PGF, a reliable indicator of oxidative stress, and cytokine-related inflammatory mediators and indicators in healthy subjects and in a population-based cohort of Swedish men.

PGF and 8-iso-PGF formation in healthy subjects varied considerably between days with a mean intra-individual coefficient of variation of 41 % and 42 %, respectively. A morning urine sample reflected the basal level of 8-iso-PGF formation as accurately as a 24-hour urine collection, and represents a more practical alternative to the 24-hour urine collection in clinical studies. PGF formation (as measured by urinary 15-keto-dihydro-PGF) was increased in patients with type 2 diabetes and in smokers independent of other cardiovascular risk factors. These results indicated an on-going cyclooxygenase (COX)-mediated inflammatory reaction related to these conditions. Further, an increased formation of isoprostanes (as measured by urinary 8-iso-PGF) was found in patients with type 2 diabetes and in smokers, indicating a high level of oxidative stress in these men. The smokers had also increased levels of the cytokine interleukin-6, indicating an on-going cytokine-related inflammatory reaction. The inflammatory indicators C-reactive protein and serum amyloid A were related to overweight but not independently associated to type 2 diabetes. High levels of serum selenium in middle-aged men predicted reduced formation of PGF and 8-iso-PGF 27 years later.

In summary, low-grade, chronic COX-mediated and possibly cytokine-related inflammation, and oxidative stress, seem to be joint features of type 2 diabetes and smoking, two major risk factors of atherosclerosis, in elderly men. Inflammation and oxidative stress may represent a possible common pathogenetic link between established risk factors for atherosclerosis and atherogenesis.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 82 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 9
Keyword
Public health, prostaglandin F2α, F2-isoprostane, interleukin-6, C-reactive protein, serum amyloid A, tocopherols, cardiovascular risk factors, variation, inflammation, oxidative stress, human, Folkhälsomedicin
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-4803 (URN)91-554-6156-5 (ISBN)
Public defence
2005-04-01, Auditorium Minus, Museum Gustavianum, Akademigatan 3, Uppsala, 09:15
Opponent
Supervisors
Available from: 2005-03-10 Created: 2005-03-10Bibliographically approved

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