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Serum selenium predicts levels of F2-isoprostanes and prostaglandin F2alpha in a 27 year follow-up study of Swedish men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
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2005 (English)In: Free radical research, ISSN 1071-5762, E-ISSN 1029-2470, Vol. 39, no 7, 763-770 p.Article in journal (Refereed) Published
Abstract [en]

Low concentrations of selenium (Se) predict mortality and cardiovascular diseases in some populations. The effect of Se on in vivo indicators of oxidative stress and inflammation, two important features of atherosclerosis, in human populations is largely unexplored. This study investigated the longitudinal association between serum selenium (s-Se) and a golden standard indicator of oxidative stress in vivo (8-iso-prostaglandin F2, a major F2-isoprostane), an indicator of cyclooxygenase (COX)-mediated inflammation (prostaglandin F2), high sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and serum amyloid A protein (SAA) in a follow-up study of 27 years. The s-Se was measured in 615 Swedish men at 50 years of age in a health investigation. The status of oxidative stress and inflammation was evaluated in a re-investigation 27 years later by quantification of urinary 8-iso-PGF2 and 15-keto-dihydro- PGF2 (a major metabolite of PGF2) and serum hsCRP, SAA and IL-6. Men in the highest quartile of s-Se at age 50 had decreased levels of 8-iso-PGF2 compared to all lower quartiles   and decreased levels of PGF2 compared to all lower quartiles   at follow-up. These associations were independent of BMI, diabetes, hyperlipidemia, hypertension, smoking, -tocopherol and β-carotene at baseline. The s-Se was not associated with hsCRP, SAA or IL-6 at follow-up. In conclusion, high concentrations of s-Se predict reduced levels of oxidative stress and subclinical COX-mediated (but not cytokine-mediated) inflammation in a male population. The associations between Se, oxidative stress and inflammation, respectively, might be related to the proposed cardiovascular protective property of Se.

Place, publisher, year, edition, pages
2005. Vol. 39, no 7, 763-770 p.
Keyword [en]
Aged, Biological Markers/blood/urine, C-Reactive Protein/metabolism, Cardiovascular Diseases/blood/epidemiology/urine, Cohort Studies, Diet, Dinoprost/*analogs & derivatives/urine, Follow-Up Studies, Humans, Inflammation/blood, Inflammation Mediators/blood, Interleukin-6/blood, Isoprostanes/*pharmacology, Longitudinal Studies, Male, Middle Aged, Oxidative Stress, Radioimmunoassay, Selenium/administration & dosage/*blood, Serum Amyloid A Protein/metabolism, Sweden/epidemiology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-92657DOI: 10.1080/10715760500108513PubMedID: 16036356OAI: oai:DiVA.org:uu-92657DiVA: diva2:165818
Available from: 2005-03-10 Created: 2005-03-10 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Prostaglandins and Isoprostanes in Relation to Risk Factors for Atherosclerosis: Role of Inflammation and Oxidative Stress
Open this publication in new window or tab >>Prostaglandins and Isoprostanes in Relation to Risk Factors for Atherosclerosis: Role of Inflammation and Oxidative Stress
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Inflammation and oxidative stress may be involved in atherogenesis. This thesis describes clinical studies of prostaglandin F (PGF), an inflammatory mediator, and the isoprostane 8-iso-PGF, a reliable indicator of oxidative stress, and cytokine-related inflammatory mediators and indicators in healthy subjects and in a population-based cohort of Swedish men.

PGF and 8-iso-PGF formation in healthy subjects varied considerably between days with a mean intra-individual coefficient of variation of 41 % and 42 %, respectively. A morning urine sample reflected the basal level of 8-iso-PGF formation as accurately as a 24-hour urine collection, and represents a more practical alternative to the 24-hour urine collection in clinical studies. PGF formation (as measured by urinary 15-keto-dihydro-PGF) was increased in patients with type 2 diabetes and in smokers independent of other cardiovascular risk factors. These results indicated an on-going cyclooxygenase (COX)-mediated inflammatory reaction related to these conditions. Further, an increased formation of isoprostanes (as measured by urinary 8-iso-PGF) was found in patients with type 2 diabetes and in smokers, indicating a high level of oxidative stress in these men. The smokers had also increased levels of the cytokine interleukin-6, indicating an on-going cytokine-related inflammatory reaction. The inflammatory indicators C-reactive protein and serum amyloid A were related to overweight but not independently associated to type 2 diabetes. High levels of serum selenium in middle-aged men predicted reduced formation of PGF and 8-iso-PGF 27 years later.

In summary, low-grade, chronic COX-mediated and possibly cytokine-related inflammation, and oxidative stress, seem to be joint features of type 2 diabetes and smoking, two major risk factors of atherosclerosis, in elderly men. Inflammation and oxidative stress may represent a possible common pathogenetic link between established risk factors for atherosclerosis and atherogenesis.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 82 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 9
Keyword
Public health, prostaglandin F2α, F2-isoprostane, interleukin-6, C-reactive protein, serum amyloid A, tocopherols, cardiovascular risk factors, variation, inflammation, oxidative stress, human, Folkhälsomedicin
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-4803 (URN)91-554-6156-5 (ISBN)
Public defence
2005-04-01, Auditorium Minus, Museum Gustavianum, Akademigatan 3, Uppsala, 09:15
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Supervisors
Available from: 2005-03-10 Created: 2005-03-10Bibliographically approved

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Helmersson, JohannaÄrnlöv, JohanVessby, BengtLarsson, AndersBasu, Samar

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