uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Conjugated linoleic acid induces lipid peroxidation in humans
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition Research.
2000 In: FEBS Letters, ISSN 0014-5793, Vol. 468, no 1, 33-36 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2000. Vol. 468, no 1, 33-36 p.
Identifiers
URN: urn:nbn:se:uu:diva-92706OAI: oai:DiVA.org:uu-92706DiVA: diva2:165882
Available from: 2005-03-23 Created: 2005-03-23Bibliographically approved
In thesis
1. Milk Fat Intake and Conjugated Linoleic Acid (CLA) Supplementation: Dietary Markers and Associations to Clinical and Biochemical Characteristics
Open this publication in new window or tab >>Milk Fat Intake and Conjugated Linoleic Acid (CLA) Supplementation: Dietary Markers and Associations to Clinical and Biochemical Characteristics
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In the present thesis dietary markers for intake of milk fat, associations between intake of milk fat and risk factors for coronary heart disease (CHD), and the effects of supplementation with conjugated linoleic acid (CLA) to healthy humans are investigated.

The dietary fat quality is one of the main lifestyle factors affecting risk for CHD. When studying the associations between diet and health it is important to have accurate dietary information. Objective dietary markers increase the possibilities to interpret dietary surveys.

In a study of 62 men we demonstrated that the milk fatty acid pentadecanoic acid (15:0) measured in serum lipids can be used as marker for intake of fat from milk products. In the same study we observed inverse correlations between intake of milk fat and certain risk factors for CHD, especially anthropometric variables.

To further investigate these findings we supplemented humans with CLA, naturally present in milk. CLA has in animals and in vitro been ascribed positive effects on adiposity and glucose and lipid metabolism. When supplementing humans with CLA we observed a slight decrease in body fat, but no effects on other anthropometric variables or serum lipids. However, markers of lipid peroxidation and inflammation increased. From a second supplementation study we concluded that CLA trans 10, cis 12 induced lipid peroxidation more than did a mixture of isomers.

We conclude that the inverse associations between milk fat intake and CHD risk factors, and the effects of CLA, are interesting and need further investigation. However, according to current knowledge, the general population is still advised to have a limited intake of total and saturated fat and to instead choose unsaturated fats. In addition, there is to date no medical reasons for humans to take CLA as supplements.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 67 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 16
Keyword
Nutrition, Pentadecanoic acid (15:0), milk products, milk fat, dietary marker, coronary heart disease, anthropometric variables, conjugated linoleic acid (CLA), lipid peroxidation, inflammation, F2 isoprostane, prostaglandin F2, human, Näringslära
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:uu:diva-4820 (URN)91-554-6170-0 (ISBN)
Public defence
2005-04-14, Auditorium Minus, Gustavianum, Akademigatan 3, Uppsala, 09:15
Opponent
Supervisors
Available from: 2005-03-23 Created: 2005-03-23Bibliographically approved

Open Access in DiVA

No full text

By organisation
Clinical Nutrition Research

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 395 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf