Conjugated linoleic acid increased C-reactive protein in human subjects
2005 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 94, no 5, 791-795 p.Article in journal (Refereed) Published
We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F2alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.
Place, publisher, year, edition, pages
2005. Vol. 94, no 5, 791-795 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-92707DOI: 10.1079/BJN20041419PubMedID: 16277783OAI: oai:DiVA.org:uu-92707DiVA: diva2:165883