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Insomnia: Prevalence, longitudinal course and health consequences - a twelve year perspective
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
2000 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim of this thesis is to investigate different aspects of insomnia by following a middle-aged population over a twelve-year period. In the present series of studies insomnia is defined as a complaint of either difficulties initiating sleep (DIS), difficulties maintaining sleep (DMS) or early morning awakenings (EMA).

In 1983 a study of 1,870 subjects aged 45-65 years was performed, based on a questionnaire that focused on sleep and health. Twelve years later, 74.1% of the surviving study population participated in a follow-up study and answered an almost identical questionnaire. The prevalence rate of insomnia at follow-up was 20.4% with a female preponderance. Depression was the variable most consistently related to insomnia while older age was not, when a simultaneous control for the effects of age, gender, depression and anxiety was carried out. A majority of those with insomnia in 1983 also reported insomnia at follow-up. Females complaining of insomnia in 1983 had a four-fold increased risk of being depressed twelve years later independent of depression status at baseline.

Mortality data were collected, and males reporting DIS ran a three-fold increased risk of coronary artery disease mortality over the twelve-year period when adjustment was made for several important risk factors.

In conclusion, insomnia is a highly prevalent and long-lasting complaint and implies a risk for subsequent depression in females. Furthermore, DIS is an important risk factor for coronary artery disease mortality in males.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2000. , 66 p.
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 964
Keyword [en]
Neurosciences, Insomnia, Epidemiology, Prospective, Older Adults, Course, Depression, Anxiety, Mortality
Keyword [sv]
National Category
Research subject
URN: urn:nbn:se:uu:diva-518ISBN: 91-554-4835-6OAI: oai:DiVA.org:uu-518DiVA: diva2:166008
Public defence
2000-11-16, Auditorium Minus, Gustavianum, Uppsala, 09:15
Available from: 2000-10-26 Created: 2000-10-26Bibliographically approved

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