Anabolic-androgenic steroids affect the content of substance P and substance P(1-7) in the rat brain
2000 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 21, no 6, 845-852 p.Article in journal (Refereed) Published
The effects of intramuscular (i.m.) injections of nandrolone decanoate (15 mg/kg/day), an anabolic-androgenic steroid, on the levels of substance P (SP) and on its N-terminal fragment SP(1-7) were examined in the male rat brain by radioimmunoassay. The results demonstrated that the SP immunoreactivity in amygdala, hypothalamus, striatum, and periaqueductal gray was significantly enhanced, whereas the concentration of the N-terminal fragment SP(1-7) was enhanced in the nucleus accumbens and in periaqueductal gray. In the striatum the steroid induced a decrease in the content of SP(1-7). The relevance of these peptides in connection with anabolic-androgenic steroid-induced aggression is discussed.
Place, publisher, year, edition, pages
2000. Vol. 21, no 6, 845-852 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-92903DOI: 10.1016/S0196-9781(00)00218-7PubMedID: 10959007OAI: oai:DiVA.org:uu-92903DiVA: diva2:166219