uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The impact of chronic nandrolone decanoate administration on the expression of the NK1 receptor density in rat brain as determined by autoradiography
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2005 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 26, no 7, 1228-1234 p.Article in journal (Refereed) Published
Abstract [en]

Adult male Sprague–Dawley rats were treated with the anabolic androgenic steroid nandrolone decanoate (15 mg/kg day) or oil vehicle (sterile arachidis oleum) during 14 days. The effect on the densities of the neurokinin NK1 receptor in brain was examined with autoradiography. An overall tendency of attenuation of NK1 receptor density was observed after completed treatment with nandrolone decanoate. The density of the NK1 receptor was found to be significantly lower compared to control animals in the nucleus accumbens core (37% density reduction), in dentate gyrus (26%), in basolateral amygdaloid nucleus (23%), in ventromedial hypothalamic nucleus (36%), in dorsomedial hypothalamic nucleus (43%) and finally in the periaqueductal gray (PAG) (24%). In the cortex region, no structures exhibited any significant reduction of NK1 receptor density. This result provides additional support to the hypothesis that substance P and the NK1 receptor may be involved as important components that participate in mediating physiological responses including the adverse behaviors often associated with chronically administrated anabolic androgenic steroids in human.

Place, publisher, year, edition, pages
2005. Vol. 26, no 7, 1228-1234 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-92904DOI: 10.1016/j.peptides.2005.02.005OAI: oai:DiVA.org:uu-92904DiVA: diva2:166220
Available from: 2005-04-18 Created: 2005-04-18 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Anabolic Androgenic Steroids: Effects on Neuropeptide Systems in the Rat Brain
Open this publication in new window or tab >>Anabolic Androgenic Steroids: Effects on Neuropeptide Systems in the Rat Brain
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Anabolic-androgenic steroids (AAS) have been used in clinics for decades. The misuse of AAS has previously been attributed merely to sport athletes, taking AAS with intentions to increase muscle mass, enhance physical performance and to improve results in competitions. Today, the misuse of AAS has spread to adolescents and young adults not connected to sports. Alarmingly, many reports are pointing at severe psychiatric adverse effects among AAS abusers, which include mood swings, mania, anxiety, depression and aggression. Numerous examples of severe and often unprovoked violence and brutal crimes have been connected to AAS abuse and there is a strong need for a better understanding of the underlying biochemical events that might account for the adverse behaviors induced by AAS. The general aim of this thesis was to study the effect of chronic AAS administration on neuropeptide circuits in the rat brain associated with the regulation of rewarding effects, memory, anxiety, depression and aggression, using nandrolone decanoate as a prototype AAS.

Results demonstrated that daily administration of AAS to rats in doses comparable to those taken by AAS abusers, in certain brain structures significantly affected, a) the levels of the opioid peptides dynorphin B and Met-enkephalin-Arg6Phe7, b) the levels of the tachykinin substance P (SP), c) the density of the SP neurokinin 1 (NK1) receptor, d) the level of the SP metabolite SP1-7 that frequently exerts opposite effects to SP, e) the SP1-7 generating enzyme substance P endopeptidase (SPE) and finally, f) the levels of the neuropeptide calcitonin gene-related peptide (CGRP) often co-localized with SP. The alterations seen in the levels and activities of these neurochemical components are in many aspects compatible with behaviors typified among AAS abusers.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 60 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, ISSN 1651-6192 ; 9
Keyword
Biological research on drug dependence, Anabolic androgenic steroids, Nandrolone decanoate, Substance P, NK1 receptor, Substance P(1-7), Endopeptidase, Opioids, Calcitonin gene-related peptide, Radioimmunoassay, Autoradiography, Central nervous system, Rats, Biologisk beroendeforskning
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:uu:diva-5745 (URN)91-554-6214-6 (ISBN)
Public defence
2005-05-11, B41, BMC, Husargatan 3, Uppsala, 09:15
Opponent
Supervisors
Available from: 2005-04-18 Created: 2005-04-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Hallberg, Mathias

Search in DiVA

By author/editor
Hallberg, Mathias
By organisation
Department of Pharmaceutical Biosciences
In the same journal
Peptides
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 524 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf