Increasing Rates and Scope of Reactions: Sluggish Amines in Microwave-Heated Aminocarbonylation Reactions under Air
2003 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 68, no 14, 5750-5753 p.Article in journal (Refereed) Published
Commercially available molybdenum hexacarbonyl serves as a convenient and solid carbon monoxide source in palladium-catalyzed aminocarbonylations of aryl bromides and iodides. This improved microwave protocol, relying on DBU as base and THF as solvent, enables rapid couplings using otherwise sluggish anilines, tert-butylamine, and free amino acids. In addition, Cr(CO)6 and W(CO)6 were found to be useful alternative CO-releasing reagents. Altogether, 16 different aromatic amides were synthesized under air in 35−95% yield after only 15 min of controlled microwave irradiation.
Place, publisher, year, edition, pages
2003. Vol. 68, no 14, 5750-5753 p.
IdentifiersURN: urn:nbn:se:uu:diva-93072DOI: 10.1021/jo034382dOAI: oai:DiVA.org:uu-93072DiVA: diva2:166439