Reduced hemodialysis adequacy after hemoglobin normalization with epoetin
2005 (English)In: JN. Journal of Nephrology (Milano. 1992), ISSN 1121-8428, Vol. 18, no 1, 80-85 p.Article in journal (Refereed) Published
BACKGROUND: Increased hemoglobin (Hb) levels and higher blood viscosity could reduce hemodialyzer clearance. We examined hemodialysis (HD) adequacy after treatment with epoetin alfa aimed at normalizing Hb levels.
METHODS: Thirty-three HD patients were randomly allocated to achieve a normal Hb level (135-160 g/L) or a subnormal (control) Hb level of 90-120 g/L. HD adequacy was assessed by Kt/V measurement.
RESULTS: In the 24 evaluable patients, Hb levels reached 144 +/- 11 g/L in the normal Hb group (n=10) and 109 +/- 10 g/L in the subnormal group (n=14). Single-pool Kt/V decreased from 1.25 +/- 0.19 to 1.15 +/- 0.13 (p<0.01) in the normal Hb group, but remained constant in the subnormal group (1.26 +/- 0.26 and 1.26 +/- 0.28).
CONCLUSIONS: Normalization of Hb with epoetin alfa in HD patients resulted in a slight but statistically significant reduction in Kt/V. Therefore, when Hb is normalized, an increased dialysis dose could be necessary to maintain dialysis adequacy
Place, publisher, year, edition, pages
2005. Vol. 18, no 1, 80-85 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-93119PubMedID: 15772927OAI: oai:DiVA.org:uu-93119DiVA: diva2:166499