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Synthesis of Ethylene Glycol bis(succinimidyl succinate): Concept study of an in-house production of key chemical used for manufacturing of a Multiplex Immunoassay chip
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering.
2022 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

The Ethylene glycol bis(succinimidyl succinate), EGS, batches received from an external supplier, that are used for ThermoFisher's Immuno Solid-phase Allergen Chip (ImmunoCAP ISAC) - tests have been malfunctioning, despite approved certificate of analysis (CoA). EGS is a key chemical needed for chemical activation of the glass slides that make up the Multiplex Immunoassay chips, hence in-house production of EGS is suggested in order to gain control of the batch quality. The purpose of this project is to analyze the technical and economical feasibility of producing EGS internally. This literature study examines the synthesis route of the coupling chemical, the purification and analytical equipment required for upscaling, SWOT-analysis for the production, Calculations of Goods Sold (COGS) and Environment, Health & Safety (EHS) management. The total cost of producing 500g of EGS internally is estimated to be ∼42,159.0 - 45,629.0 SEK, or, ∼84.3 - 91.3 SEK/g, saving 250,000 - 750,000 SEK compared to buying EGS from an external supplier. If an intermediate was to be purchased, the company would save between 200,000 - 700,000 SEK. Tetrahydrofuran (THF) which is used when synthesizing the intermediate is categorized as very hazardous and is suspected of causing cancer by REACH, Registration, Evaluation, Authorisation, and restriction of Chemicals, European Union s regulatory law for the production, registration, usage and regulation of chemical substances. The handling of this chemical is avoided if the intermediate is received from a supplier, which in turn is beneficial from an EHS-perspective. Producing EGS either from scratch or by first purchasing the intermediate and then proceeding with the synthesis of EGS, proves to be economically favorable. 

Place, publisher, year, edition, pages
2022. , p. 25
Series
MATVET-K ; 22009
Keywords [en]
Ethylene glycol bis(succinimidyl succinate), Coupling chemical, Substitution reaction, Esterification, ImmunoCAP ISAC-tests
National Category
Chemical Engineering
Identifiers
URN: urn:nbn:se:uu:diva-476404OAI: oai:DiVA.org:uu-476404DiVA, id: diva2:1666754
External cooperation
ThermoFisher Scientific
Subject / course
Chemistry
Educational program
Master Programme in Chemical Engineering
Supervisors
Examiners
Available from: 2023-07-03 Created: 2022-06-09 Last updated: 2023-07-03Bibliographically approved

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