Low mRNA levels of RGS4 splice variants in Alzheimer’s disease and association between a rare haplotype and decreased mRNA expression
2006 (English)In: Synapse, ISSN 0887-4476, E-ISSN 1098-2396, Vol. 59, no 3, 173-176 p.Article in journal (Refereed) Published
Regulator of G-protein signaling 4 (RGS4) showed decreased mRNAlevels in Alzheimer’s disease in a large collection of human brain autopsies from prefrontalcortex. The expression levels of three RGS4 splice variants were examined inthe same samples, and the association between RGS4 gene expression and/or the diseasewith single nucleotide polymorphisms located in this gene was explored. We showthat all splice variants are down-regulated in patients. We also demonstrate that onerare haplotype (ATAG) is associated with decreased mRNA levels in both cases andcontrols. Our results suggest that an altered regulation in transcription initiation maybe an important mechanism for low RGS4 protein levels in Alzeimer’s disease.
Place, publisher, year, edition, pages
2006. Vol. 59, no 3, 173-176 p.
neurodegeneration, RGS splice variants, SNP, real-time RT-PCR
IdentifiersURN: urn:nbn:se:uu:diva-93408DOI: 10.1002/SYN.20226PubMedID: 16358332OAI: oai:DiVA.org:uu-93408DiVA: diva2:166872