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Computational inference of scenarios for alpha-proteobacterial genome evolution
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Department of Evolution, Genomics and Systematics, Molecular Evolution.
2004 In: Proceedings of the national academy of sciences USA, ISSN 1091-6490, Vol. 101, no 26, 9722-9727 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2004. Vol. 101, no 26, 9722-9727 p.
URN: urn:nbn:se:uu:diva-93417OAI: oai:DiVA.org:uu-93417DiVA: diva2:166883
Available from: 2005-09-09 Created: 2005-09-09Bibliographically approved
In thesis
1. Lifestyle and Genome Evolution in Vector-Borne Bacteria: A Comparison of Three Bartonella Species
Open this publication in new window or tab >>Lifestyle and Genome Evolution in Vector-Borne Bacteria: A Comparison of Three Bartonella Species
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Alternative title[sv]
Livsstil och genomevolution i vektorburna bakterier : en jämförelse av tre Bartonella-arter
Abstract [en]

Bacterial genomes provide records of the molecular processes associated with emergence and evolution of different bacterial lifestyles. This thesis is based on whole-genome comparisons within the genus Bartonella, an excellent model system for studies of host- and vector-specificity and infection outcome in animal-associated bacteria. The louse-borne human specialist and trench fever agent Bartonella quintana was contrasted to the flea-borne generalist relatives Bartonella henselae and Bartonella grahamii, which cause asymptomatic infection in cat and mouse respectively. While B. henselae is commonly isolated from humans, and causes cat scratch disease, there is only one reported case of B. grahamii human infection.

The gene complements of the three species are nested like Russian dolls with the smaller genome (B. quintana) being entirely contained in the medium sized (B. henselae), which in turned is contained in the largest (B. grahamii). Size differences reflect differences in the horizontally and vertically acquired gene content, and in the number of genus- and species- specific genes, owing to differential impact of bacteriophages and plasmids, and to different degrees of genome decay. These processes can be attributed to the three distinct lifestyles.

Comparisons with other alpha-proteobacteria suggest that the Bartonella genus as a whole evolved from plant-associated species, and that horizontal transfer, in particular of genes involved in interaction with the host, played a key role in the transition to animal intracellular lifestyle. The long-term genome decay associated with this lifestyle is most advanced in the host-restricted B. quintana. The broad host-range species B. grahamii has the largest genome and the largest proportion of auxiliary DNA of the three, probably because it has access to a larger gene pool. In encodes all the known pathogenicity determinants found in the genomes of B. henselae and B. quintana, suggesting that these genes primarily evolved to facilitate colonization in the reservoir host.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 57 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 87
Biology, Bartonella, evolution, host-restriction, vector-borne, horizontal gene transfer, genome reduction, alpha-proteobacteria, Type-IV secretion, Biologi
National Category
Biological Sciences
urn:nbn:se:uu:diva-5913 (URN)91-554-6326-6 (ISBN)
Public defence
2005-09-30, Zootissalen, Evolutionsbiologiskt centrum, Villavägen 9, Uppsala, 13:00 (English)
Available from: 2005-09-09 Created: 2005-09-09 Last updated: 2009-08-04Bibliographically approved

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