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Neutrophils from Term and Preterm Newborn Infants Express the High Affinity Fcγ-Receptor I (CD64) During Bacterial Infections
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
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1999 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 45, no 6, 871-876 p.Article in journal (Refereed) Published
Abstract [en]

The high affinity Fcgamma-receptor I (FcgammaRI, CD64) is normally expressed only to a very low extent by neutrophils. During bacterial infections, however, neutrophils from adult patients significantly increase their expression of FcgammaRI. Stimulation through FcgammaRI is a highly effective way to improve various aspects of neutrophil function, including phagocytosis. In our study the expression of FcgammaRI on neutrophils from preterm (n = 9) and term (n = 3) newborn infants, children (n = 14), and adults (n = 6) during the early phase of an acute bacterial infection was investigated. Our results showed that neutrophils from newborn infants with bacterial infection expressed FcgammaRI to a significantly higher extent than both noninfected preterm (p < 0.001) and term (p < 0.001) newborn infants and that neutrophils from preterm neonates expressed FcgammaRI to the same extent as neutrophils from term neonates and older infants, children, and adults. No difference in the neutrophil cell surface expression of FcgammaRI during bacterial infections was found among newborn infants, children, and adults. Expression of FcgammaRI probably represents an important mechanism to improve neutrophil phagocytosis as well as other aspects of neutrophil function during bacterial infections, especially in preterm infants. Our study indicates that measurement of cell surface expression of FcgammaRI on neutrophils could be a useful indicator of severe bacterial infections in preterm and term neonates, as well as in older children and adults.

Place, publisher, year, edition, pages
1999. Vol. 45, no 6, 871-876 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-93547PubMedID: 10367781OAI: oai:DiVA.org:uu-93547DiVA: diva2:167056
Available from: 2005-10-04 Created: 2005-10-04 Last updated: 2017-12-14Bibliographically approved
In thesis
1. CD64 (FcγRI) Expression on Neutrophil Granulocytes: A Diagnostic Marker of Acute Bacterial Infections
Open this publication in new window or tab >>CD64 (FcγRI) Expression on Neutrophil Granulocytes: A Diagnostic Marker of Acute Bacterial Infections
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Background. Newborn infants, especially preterm infants, have an increased susceptibility to serious and overwhelming bacterial as well as fungal infections. Symptoms of septicaemia in especially the very preterm neonates are vague and unspecific. No really good biochemical parameter exists today that can confirm or exclude the existence of neonatal septicaemia. The access to such a test in neonates would be most valuable, not only to assure early institution of effective antibiotic therapy when needed, but also to avoid unnecessary use of antibiotics, thereby reducing the risk of further development of antimicrobial resistance.

Aim. To investigate the possible use of the expression of the phagocyte receptor CD64 (FcγRI) on neutrophils for early diagnosis of bacterial infections with special reference to neonatal septicaemia.

Results. Neutrophils from preterm and term newborn infants, older infants, children, and adults examined during the early phase of a bacterial infection showed a significantly higher expression of CD64 compared with non-infected controls (p<0.001). Neutrophils from even extremely preterm infants expressed CD64 to the same extent as did neutrophils from children and adult patients. The expression of CD64 was not affected by the respiratory distress syndrome (RDS) or by such factors as premature rupture of the membranes, gestational age, steroid treatment before delivery, method of delivery, birth weight or postnatal age.

Major surgery in adults (total hip replacement) did not affect the CD64 expression to an extent comparable to that found during bacterial infections. Indirectly CD64 was found to be at least equal to CRP for differentiation between Influenza A infection and bacterial infections in adults.

Conclusion. CD64 was found to be a specific and reliable marker for early detection of bacterial infections in preterm and term newborn infants, as well as after surgery. For differentiation between bacterial and viral infections it is probably at least as effective as CRP.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 56 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 76
Keyword
Pediatrics, CD64, FcγRI, Neutrophil, Infection, Newborn, Neonate, Pediatrik
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-5974 (URN)91-554-6358-4 (ISBN)
Public defence
2005-10-26, Rosensalen, Akademiska Barnsjukhuset, Uppsala, 09:15
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Available from: 2005-10-04 Created: 2005-10-04Bibliographically approved

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