uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The effect of perioperative corticosteroids on the outcome of microscopic lumbar disc surgery
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
Show others and affiliations
2003 In: European Spine Journal, Vol. 12, 625-630 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2003. Vol. 12, 625-630 p.
URN: urn:nbn:se:uu:diva-93723OAI: oai:DiVA.org:uu-93723DiVA: diva2:167292
Available from: 2005-11-11 Created: 2005-11-11Bibliographically approved
In thesis
1. Corticosteroids in Lumbar Disc Surgery
Open this publication in new window or tab >>Corticosteroids in Lumbar Disc Surgery
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In a prospective randomised double-blind study eighty patients with MRI verified lumbar disc herniation and corresponding clinical findings underwent microscopic disc removal. The patients were peroperatively given systemic and local corticosteroids or placebo, and followed for 2 years. The hospital stay and time to return to full-time work was significantly shorter in the treatment group. Pain measured as worst pain during the last week was also lower in the corticosteroid group. The results indicate that peroperative treatment with corticosteroids reduces pain and improves the functional outcome in patients operated for lumbar disc herniations.

To evaluate whether thermal quantitative sensory testing (QST) is applicable in the study of sensory dysfunction in lumbar disc herniations 66 patients with disc herniations underwent thermal QST. We found that thermal QST reflects sensory dysfunction in patients with lumbar disc herniations. However, thermal QST seems to have a poor predictive value for identifying the anatomic location of a herniated lumbar disc.

Quantitative sensory testing (QST) was used to detect damage to the myelinated A-delta fibres (cold sense) and the unmyelinated C-fibres (warmth sense). Corticosteroids combined with surgery in lumbar disc surgery improved the normalisation for the warmth disturbance compared to the control group.

A prospective analysis was performed on the predictive value of preoperatively determined lumbar lordosis and flexion for pain and disability in patients treated by microscopic lumbar disc surgery. Preoperative hyperlordosis correlated to more pain postoperatively (p=0.004). In patients with hypoflexion there was an association between hyperlordosis and moderate or severe pain postoperatively (p<0.001). The same outcomes were found for DRI. The stiff and straight back indicates a good outcome of lumbar disc surgery concerning pain and disability.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 31 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 84
Surgery, lumbar disc heniation, corticosteroids, outcome, thermal quantitative sensory testing, QST, VAS, disability rating index, DRI, microscopic discectomy, Kirurgi
National Category
urn:nbn:se:uu:diva-6126 (URN)91-554-6395-9 (ISBN)
Public defence
2005-12-02, Wilandersalen, M-huset, Universitetssjukhuset, Örebro, 13:15
Available from: 2005-11-11 Created: 2005-11-11Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Surgical Sciences

Search outside of DiVA

GoogleGoogle ScholarTotal: 3 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 120 hits
ReferencesLink to record
Permanent link

Direct link