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Clinical validation in a nested case-control study of self-reported airway, nose and skin symptoms in children
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
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Article in journal (Refereed) Submitted
URN: urn:nbn:se:uu:diva-93780OAI: oai:DiVA.org:uu-93780DiVA: diva2:167364
Available from: 2005-11-17 Created: 2005-11-17Bibliographically approved
In thesis
1. Epidemiological Aspects of Asthma in Primary Care: Special Reference to Prevalence, Clinical Detection and Validation
Open this publication in new window or tab >>Epidemiological Aspects of Asthma in Primary Care: Special Reference to Prevalence, Clinical Detection and Validation
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Objectives. To describe the prevalence of asthma in a mid-Swedish region and measure the detection rate of asthma in primary care. To compare clinical outcomes for adolescents with asthma in primary care or in paediatric care and to perform a clinical validation in children with airway, nose and skin symptoms.

Material and methods. A questionnaire survey of respiratory symptoms and disease in an adult population and an investigation of the occurrence of clinically detected asthma in primary care. A cross-sectional study comparing management, asthma control and quality of life in adolescents. The last study was a nested case-control study with a clinical validation of reported allergic symptoms in children.

Results. The prevalence of asthma in the adult population was 8%. The clinical prevalence of asthma in primary care was 2%. The detection rate was higher in primary health care centres with asthma clinics, as compared to primary care without such clinics. In adolescents with asthma there was no difference in clinical outcomes between primary care and paediatric care. The validation study showed a high correlation between assigned cases and disease.

Conclusions. Asthma is a common disease where the majority of cases are managed in primary care. Many cases are, however, not diagnosed and the detection rate becomes a quality care indicator. The study of adolescents confirms that proactive care can be further improved regardless of whether their management is in primary or paediatric care. The nested case-control design is suitable to suggest causational risk factors for asthma and for prediction of allergic disease development.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2005. 66 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 90
Medicine, Adult, Adolescent, Asthma, Case-Control Studies, Causality, Child, Cross-Sectional Studies, Diagnosis Computer-Assisted, Epidemiology, Prevalence, Primary Health Care, Validation Studies, Medicin
National Category
Dermatology and Venereal Diseases
urn:nbn:se:uu:diva-6144 (URN)91-554-6406-8 (ISBN)
Public defence
2005-12-09, Rudbeckssalen, Rudbeckslaboratoriet, Uppsala Science Park, Uppsala, 13:15
Available from: 2005-11-17 Created: 2005-11-17 Last updated: 2011-05-13Bibliographically approved

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