Origin of the prolactin-releasing hormone (PRLH) receptors: Evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution
2005 (English)In: Genomics, ISSN 0888-7543, E-ISSN 1089-8646, Vol. 85, no 6, 688-703 p.Article in journal (Refereed) Published
We present seven new vertebrate homologs of the prolactin-releasing hormone receptor (PRLHR) and show that these are found as two separate subtypes, PRLHR1 and PRLHR2. Analysis of a number of vertebrate sequences using phylogeny, pharmacology, and paralogon analysis indicates that the PRLHRs are likely to share a common ancestry with the neuropeptide Y (NPY) receptors. Moreover, a micromolar level of NPY was able to bind and inhibit completely the PRLH-evoked response in PRLHR1-expressing cells. We suggest that an ancestral PRLH peptide started coevolving with a redundant NPY binding receptor, which then became PRLHR, approximately 500 million years ago. The PRLHR1 subtype was shown to have a relatively high evolutionary rate compared to receptors with fixed peptide preference, which could indicate a drastic change in binding preference, thus supporting this hypothesis. This report suggests how gene duplication events can lead to novel peptide ligand/receptor interactions and hence spur the evolution of new physiological functions.
Place, publisher, year, edition, pages
2005. Vol. 85, no 6, 688-703 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-94034DOI: 10.1016/j.ygeno.2005.02.007PubMedID: 15885496OAI: oai:DiVA.org:uu-94034DiVA: diva2:167725