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Gene, phenotype and function: GLABROUS1 and resistance to herbivory in natural populations of Arabidopsis lyrata
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Evolution, Ecological Botany.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Evolution, Ecological Botany.
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2007 (English)In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 16, no 2, 453-462 p.Article in journal (Refereed) Published
Abstract [en]

The molecular genetic basis of adaptive variation is of fundamental importance for evolutionary dynamics, but is still poorly known. Only in very few cases has the relationship between genetic variation at the molecular level, phenotype and function been established in natural populations. We examined the functional significance and genetic basis of a polymorphism in production of leaf hairs, trichomes, in the perennial herb Arabidopsis lyrata. Earlier studies suggested that trichome production is subject to divergent selection. Here we show that the production of trichomes is correlated with reduced damage from insect herbivores in natural populations, and using statistical methods developed for medical genetics we document an association between loss of trichome production and mutations in the regulatory gene GLABROUS1. Sequence data suggest that independent mutations in this regulatory gene have provided the basis for parallel evolution of reduced resistance to insect herbivores in different populations of A. lyrata and in the closely related Arabidopsis thaliana. The results show that candidate genes identified in model organisms provide a valuable starting point for analysis of the genetic basis of phenotypic variation in natural populations.

Place, publisher, year, edition, pages
2007. Vol. 16, no 2, 453-462 p.
Keyword [en]
adaptation, Arabidopsis lyrata, association analysis, candidate gene, GLABROUS1, herbivory
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-94038DOI: 10.1111/j.1365-294X.2007.03109.xISI: 000243305200017PubMedID: 17217357OAI: oai:DiVA.org:uu-94038DiVA: diva2:167731
Available from: 2006-03-03 Created: 2006-03-03 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Ecology and Evolution of Resistance to Herbivory: Trichome Production in Arabidopsis lyrata
Open this publication in new window or tab >>Ecology and Evolution of Resistance to Herbivory: Trichome Production in Arabidopsis lyrata
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In this thesis, I examine variation in occurrence and performance of glabrous and trichome-producing plants of the perennial herb Arabidopsis lyrata. I combine field studies and genetic analysis to (1) examine the function of trichomes as a resistance character in natural populations, (2) compare the magnitude of population differentiation in trichome-production and at putatively neutral marker loci, (3) examine the molecular genetic basis of trichome-production, and (4) quantify the effects of herbivore removal on population growth and relative performance of glabrous and trichome-producing plants.

In a survey of 30 populations of A. lyrata in Norway and Sweden, I documented spatiotemporal variation in damage from insect herbivores. With few exceptions, glabrous plants were more damaged by herbivorous insects than trichome-producing plants in polymorphic populations. Damage levels varied substantially among populations and among years. The intensity of herbivory quantified as mean leaf removal to glabrous plants was higher in polymorphic populations than in monomorphic glabrous populations.

Within the Swedish range, populations were more strongly differentiated at the locus coding for glabrousness than at eight putatively neutral isozyme loci. This is consistent with the hypothesis that trichome production is subject to divergent selection.

A study of the genetic basis of trichome production showed that glabrousness was associated with mutations in an orthologue to GLABROUS1, a regulatory gene known to cause glabrousness in A. thaliana. Comparative data indicate that the genetic basis of glabrousness varies among populations.

Experimental removal of insect herbivores in a natural A. lyrata population increased population growth rate and the relative fitness of the glabrous morph. The results suggest that insect herbivory may influence both population dynamics and selection on trichome production in A. lyrata.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2006. 32 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 148
Keyword
Biology, Plant-animal interactions, herbivory, trichomes, plant resistance, plant defense, divergent selection, local adaptation, GLABROUS1, evolution, matrix population models, LTRE, Biologi
National Category
Biological Sciences
Identifiers
urn:nbn:se:uu:diva-6359 (URN)91-554-6467-X (ISBN)
Public defence
2006-03-25, Föreläsningssalen, Avdelningen för växtekologi, Villavägen 14, Uppsala, 10:00 (English)
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Available from: 2006-03-03 Created: 2006-03-03 Last updated: 2011-02-17Bibliographically approved

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Løe, GeirÅgren, Jon

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