uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Composition of the “antigenome” of Helicobacter pylori defined by human serum antibodies
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
Show others and affiliations
Manuscript (Other academic)
URN: urn:nbn:se:uu:diva-94062OAI: oai:DiVA.org:uu-94062DiVA: diva2:167780
Available from: 2006-03-03 Created: 2006-03-03 Last updated: 2010-01-13Bibliographically approved
In thesis
1. Identification and Characterization of Biomarkers in Bacterial Infections
Open this publication in new window or tab >>Identification and Characterization of Biomarkers in Bacterial Infections
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In recent years molecular biology has become an integral part of the clinical laboratory. With an ever increasing number of methodologies and applications being presented each year it has increased our knowledge of how bacteria cause disease as well as our ability to predict disease outcome.

The main focus of this thesis has been to develop methods for identifying biomarkers and prediction methods for bacterial infectious diseases by taking advantage of the ever increasing possibilities of molecular biology. We applied cutting edge techniques in order to establish novel platforms for identifying and characterizing biomarkers of disease.

In paper one we describe a novel approach to measure levels of antibiotic resistance and viability of C. trachomatis, a method that is a clear improvement over existing techniques. In the second paper we describe the development of two assays designed to type pertussis toxin subunit 1 in circulating strains, in order to facilitate multi center studies for vaccine escape surveillance. In paper three we develop a novel microarray application designed to identify a large number of bacterial traits of H. pylori simultaneously with human genetic polymorphisms in order to identify a collection of risk factors that could be used as a prediction tool for gastric cancer risk. In the last paper we define the “antigenome” of H. pylori and identified 14 promising, previously unreported antigens as well as a number of potential biomarkers.

The platform technologies described in this collection of papers will hopefully help us identifying novel ways of fighting and predicting bacterial disease in future studies.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2006. 55 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 112
Microbiology, Microbiology, Bacteriology, Chlamydia trachomatis, Bordetella perussis, Helicobacter pylori, Real-Time PCR, Microarray, Antigenome, Vaccine, Biomarker, Mikrobiologi
National Category
Microbiology in the medical area
urn:nbn:se:uu:diva-6509 (URN)91-554-6475-0 (ISBN)
Public defence
2006-03-24, Hörsalen, Klinisk Bakteriologi, Akademiska Sjukhuset ing. D1, Dag Hammarskjöldsväg 17, Uppsala, 13:15
Available from: 2006-03-03 Created: 2006-03-03Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Medical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 143 hits
ReferencesLink to record
Permanent link

Direct link